Results 141 to 150 of about 64,354 (314)
UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids
Ubxd8, a multidomain protein sensor for long-chain unsaturated fatty acids (FAs), plays a crucial role to maintain cellular homeostasis of FAs. Ubxd8 polymerizes upon interaction with long-chain unsaturated FAs, but the molecular mechanism involved in ...
Hyeonwoo Kim+5 more
doaj
Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect
Due to the synergistic effect of ENernst,H2O2${E}_{\mathrm{Nernst},\ {\mathrm{H}}_{2}{\mathrm{O}}_{2}}$ and ENernst,H+${E}_{\mathrm{Nernst},\ {\mathrm{H}}^{+}}$, the proposed sensors in this study can achieve ultralow H2O2 detection limit as low as 1.8 × 10−12 M based on the stacked PEDOT: BTB/PEDOT: PSS semiconducting layer.
Zhaoqun Wang+12 more
wiley +1 more source
Electrostatic Ratchet for Successive Peptide Synthesis in Nonribosomal Molecular Machine RimK. [PDF]
Ohnuki J+5 more
europepmc +1 more source
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou+18 more
wiley +1 more source
Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li+8 more
wiley +1 more source
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang+4 more
wiley +1 more source
FATE OF DEUTERO-LABELED CARBAMYL GLUTAMATE IN CITRULLINE BIOSYNTHESIS
Santiago Grisolı́a+2 more
openalex +1 more source
EFFECTS OF SALICYLATE ON GLUTAMATE DEHYDROGENASE AND GLUTAMATE DECARBOXYLASE [PDF]
M. J. H. Smith+2 more
openaire +3 more sources
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun+13 more
wiley +1 more source