Results 151 to 160 of about 66,132 (287)

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

Direct evidence of acid-driven protein desolvation. [PDF]

Proc Natl Acad Sci U S A
Hamdi F, Skalidis I, Schwerin IK, Belapure J, Semchonok DA, Kyrilis FL, Tüting C, Müller J, Künze G, Kastritis PL.   +9 more
europepmc   +1 more source

Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons [PDF]

Ryunosuke Amo, Naoshige Uchida, Mitsuko Watabe‐Uchida   +2 more
openalex   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Structural basis of drug recognition by human MATE1 transporter. [PDF]

Nat Commun
Romane K, Peteani G, Mukherjee S, Kowal J, Rossi L, Hou J, Kossiakoff AA, Lemmin T, Locher KP.   +8 more
europepmc   +1 more source

Arginine 447 Plays a Pivotal Role in Substrate Interactions in a Neuronal Glutamate Transporter

, 2000
Annie Bendahan, Ayelet Armon, Navid Madani, Michael P. Kavanaugh, Baruch I. Kanner   +4 more
openalex   +1 more source

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

Advanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang, Dechao Xu, Xiang Gao, Min Chen, Xiangchen Gu   +13 more
wiley   +1 more source

Identification, characterization, and structure-activity relationship of the ASIC3-selective peptide WRPRFa. [PDF]

Commun Chem
Chien C, Yang ND, Jiang V, Amagasu SM, Gilchrist JM.   +4 more
europepmc   +1 more source

Glutamate inhibition in MS: The neuroprotective properties of riluzole

, 2005
Joep Killestein, Nynke F. Kalkers, Chris H. Polman   +2 more
openalex   +2 more sources

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source