Results 151 to 160 of about 65,396 (291)

Structural basis of drug recognition by human MATE1 transporter. [PDF]

Nat Commun
Romane K, Peteani G, Mukherjee S, Kowal J, Rossi L, Hou J, Kossiakoff AA, Lemmin T, Locher KP.   +8 more
europepmc   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Light-Activatable, 2,5-Disubstituted Tetrazoles for the Proteome-wide Profiling of Aspartates and Glutamates in Living Bacteria

ACS Central Science, 2020
Kathrin Bach, Bert L. H. Beerkens, Patrick R. A. Zanon, Stephan M. Hacker   +3 more
doaj   +1 more source

Molecular simulations meet personalized medicine: The mechanism of action of CLC-5 antiporter and the origin of Dent's disease. [PDF]

PNAS Nexus
Macaluso V, Pérez C, Soliva R, Westermaier Y, Díaz L, Wieczór M, Orozco M.   +6 more
europepmc   +1 more source

Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview

, 2021
Arnab Banerjee, Sandip Mukherjee, Bithin Kumar Maji   +2 more
openalex   +1 more source

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Predicting residue ionization of OmpF channel using Constant pH Molecular Dynamics as benchmark. [PDF]

PLoS Comput Biol
Tavares-Neto E, Aguilella-Arzo M, Aguilella VM.   +2 more
europepmc   +1 more source

Charting brain GABA and glutamate levels across psychiatric disorders by quantitative analysis of 121 ¹H-MRS studies [PDF]

Jiayuan Zhang, Timothea Toulopoulou, Qian Li, Lijing Niu, Lanxin Peng, Haowei Dai, Keyin Chen, Xingqin Wang, Ruiwang Huang, Xinhua Wei, Ruibin Zhang   +10 more
openalex   +1 more source

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, EarlyView.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source

Rescue of ciliogenesis and hyperglutamylation mutant phenotype in AGBL5^-/- cell model of retinitis pigmentosa. [PDF]

BMC Mol Cell Biol
Villa-Vasquez SS, Nazlamova L, Pengelly RJ, Wilson DI, Baralle D, Wheway G.   +5 more
europepmc   +1 more source