Results 171 to 180 of about 69,631 (334)
Effects of gestational haloperidol exposure on mRNA expressions related to glutamate and GABA receptors in offspring [PDF]
, 2023 Hiroshi Kumon +5 more
openalex +1 more source
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Advanced Science, EarlyView.Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian +11 more
wiley +1 more source
3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1
, 2007 Y. Nataraja Sekhar +4 more
openalex +1 more source
Subicular Astrocytes Govern Seizure‐Impaired Fear Memory
Advanced Science, EarlyView.Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao +15 more
wiley +1 more source
Electrostatic Ratchet for Successive Peptide Synthesis in Nonribosomal Molecular Machine RimK. [PDF]
J Am Chem Soc, 2023 Ohnuki J +5 more
europepmc +1 more source
Glutamate delta-1 receptors regulate a tonic excitatory conductance in the mouse bed nucleus of the stria terminalis and influence neuronal function [PDF]
Sara Y. Conley +5 more
openalex +1 more source
Modulation of Ionotropic Glutamate Receptors and Acid-Sensing Ion Channels by Nitric Oxide [PDF]
, 2012 John Q. Wang +7 more
openalex +1 more source