Results 191 to 200 of about 65,396 (291)

REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy

Advanced Science, EarlyView.
REEP1 contributes to endoplasmic reticulum (ER) shaping. Variants either cause cortical motoneuron degeneration and hereditary spastic paraplegia (HSP) or spinal motoneuron degeneration and distal hereditary motor neuropathy (dHMN). Knockout causes less complex ER structures and cortical motoneuron loss.
Andrea Bock, Mona Schurig, Miles Willoughby, Andrea Mirecki, Eric Seemann, Kateryna Lohachova, Istvan Katona, Sonnhild Mittag, Lutz Liebmann, Patricia Franzka, Mehdi Heidari Horestani, Mukhran Khundadze, Thorsten Mosler, Timothy Louie, Marianne de Visser, Marian A. J. Weterman, Michael Kiehntopf, Christian Beetz, Sandor Nietzsche, Otmar Huber, Joachim Weis, Michael M. Kessels, Ramachandra M. Bhaskara, Britta Qualmann, Ivan Đikić, Christian A. Hübner   +25 more
wiley   +1 more source

A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis. [PDF]

Proc Natl Acad Sci U S A
Zhao K, Zhang L, Lei M, Jin Z, Du T, Zhang H, Sheng Y, Hu Z, Wang S, Ma C, Ma C.   +10 more
europepmc   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, EarlyView.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Dietary monosodium glutamate affects the growth and feed utilization of Eriocheir sinensis by regulating the appetite related genes expression

Anran Wang, Yu Fu, Longlong Fu, Mengge Li, Jie Xu, Xiangji Guo, Yuheng Wu, Xiumei Xing, Shuyan Miao   +8 more
openalex   +1 more source

Protoplast transformation of glutamate-producing bacteria with plasmid DNA [PDF]

, 1984
Ryoichi Katsumata, Aya Ozaki, Tatsuzo Oka, Akira Furuya   +3 more
openalex   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Cofactor F₄₂₀ tail length distribution in different environmental samples. [PDF]

Heliyon
Wunderer M, Markt R, Prem EM, Peer N, Mullaymeri A, Wagner AO.   +5 more
europepmc   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, EarlyView.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Rewiring the brain: abused drugs and structural plasticity

Frontiers in Pharmacology, 2015
M Foster eOlive, Justin eGass
doaj   +1 more source

Structural and functional insights into extreme thermal stability and activity of two GH12 domains of a multidomain glycosidase from a hyperthermophilic euryarchaeon. [PDF]

FEBS J
Zayulina KS, Frolov EN, Stracke C, Klyukina AA, Khusnutdinova AN, Stogios P, Skarina T, Yakunin AF, Golyshin PN, Siebers B, Shugaeva TE, Kublanov IV.   +11 more
europepmc   +1 more source