Results 231 to 240 of about 66,132 (287)

Deciphering Ca^<b>2+</b> permeation and valence selectivity in Ca_V1: Molecular dynamics simulations reveal the three-ion knock-on mechanism. [PDF]

Proc Natl Acad Sci U S A
Xue L, Yan N, Song C.
europepmc   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5. [PDF]

Nat Commun
Li M, Lan X, Shi X, Zhu C, Lu X, Pu J, Lu S, Zhang J.   +7 more
europepmc   +1 more source

The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice

Matilde Balbi, Carola Torazza, Tiziana Altosole, Silvia Ravera, Emanuele Farinini, Sara Tessitore, Francesca Bacchetti, Francesco Rosso, Ilaria Musante, Silvana Alfei, Maria Cerminara, Aldamaria Puliti, Gilberto Filaci, Daniela Fenoglio, Riccardo Leardi, Ernesto Fedele, Giambattista Bonanno, Marco Milanese, Tiziana Bonifacino   +18 more
openalex   +1 more source

Alternative Import-Channels And Destinations Of Mitochondrial PINK1 Controlled By Trans-Membrane-Domain Structural Plasticity

Lorriman JS, Grieve AG, Corey RA, Collinson I.   +3 more
europepmc   +1 more source

The role of IP₃ receptors and SERCA pumps in restoring working memory under amyloid β induced Alzheimer's disease: a modeling study. [PDF]

Front Comput Neurosci
Huang Z, Wang L.
europepmc   +1 more source

Introductory Chapter: Glutamate, a Double Edge Sword

Kaneez Fatima-Shad
openalex   +2 more sources

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +1 more source

BacA(SbmA) importer of legume symbiotic NCR peptides: Protein architecture, function, and evolutionary implications. [PDF]

Proc Natl Acad Sci U S A
Arnold MFF, Sankari S, Deutsch M, Gruber CC, Guerra-Garcia FJ, Beis K, Walker GC.   +6 more
europepmc   +1 more source