Results 251 to 260 of about 69,631 (334)

A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis. [PDF]

Proc Natl Acad Sci U S A
Zhao K, Zhang L, Lei M, Jin Z, Du T, Zhang H, Sheng Y, Hu Z, Wang S, Ma C, Ma C.   +10 more
europepmc   +1 more source

Histological Effects of Continuous Prolonged Use of Monosodium Glutamate on Kidneys of Adult Wistar Rats

, 2017
Farhana Jafri, Godfrey Paul William, Fouzia Farzana   +2 more
openalex   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Structural and functional insights into extreme thermal stability and activity of two GH12 domains of a multidomain glycosidase from a hyperthermophilic euryarchaeon. [PDF]

FEBS J
Zayulina KS, Frolov EN, Stracke C, Klyukina AA, Khusnutdinova AN, Stogios P, Skarina T, Yakunin AF, Golyshin PN, Siebers B, Shugaeva TE, Kublanov IV.   +11 more
europepmc   +1 more source

Structure–Activity Relationship Studies of Argiotoxins: Selective and Potent Inhibitors of Ionotropic Glutamate Receptors

, 2013
Mette H. Poulsen, Simon Lucas, Tinna B. Bach, Anne F. Barslund, Claudius Wenzler, Christel Barker Jensen, Anders S. Kristensen, Kristian Strømgaard   +7 more
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Long-Term Outcome of Myocardial Protection in Heart Transplantation: Comparison Among 3 Different Solutions. [PDF]

Interdiscip Cardiovasc Thorac Surg
Settepani F, Cannata A, Belluschi I, Pisani GP, Mondino MG, Garascia A, Russo CF.   +6 more
europepmc   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Structural basis of urea transport by Arabidopsis thaliana DUR3. [PDF]

Nat Commun
An W, Gao Y, Liu L, Bai Q, Zhao J, Zhao Y, Zhang XC.   +6 more
europepmc   +1 more source