Results 251 to 260 of about 226,163 (382)

Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative

Advanced Science, EarlyView.
Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen, Hsien‐Chung Chen, Chien‐Liang Lin, Amandeep Thakur, Raphael Onuku, I‐Chung Chen, Hao‐Yi Li, Kwang‐Yu Chang, Jian‐Ying Chuang, Wen‐Bin Yang, Hong‐Yi Lin, Yi‐Ru Shen, Jing‐Ping Liou, Wen‐Chang Chang, Tsung‐I Hsu   +14 more
wiley   +1 more source

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5. [PDF]

Nat Commun
Li M, Lan X, Shi X, Zhu C, Lu X, Pu J, Lu S, Zhang J.   +7 more
europepmc   +1 more source

4-Amino-4-cyanobutyric Acid as an Intermediate in Glutamate Biosynthesis

, 1967
Gary A. Strobel
openalex   +1 more source

Glutamate synthesis and the control of reactions linked with the nicotinamide-adenine dinucleotide coenzymes in mitochondria [PDF]

, 1962
E. Anthony Jones, H. Gutfreund
openalex   +1 more source

Surface grafting of poly(L-glutamates). 2. Helix orientation

, 2001
R. H. Wieringa, E. Siesling, P. Werkman, H. Angerman, E. Vorenkamp, A. Schouten   +5 more
semanticscholar   +1 more source

Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity

Advanced Science, EarlyView.
This review explores the complex and self‐reinforcing cycle of mechanical stress, inflammation, and altered vascularity in tendinopathy—a common, painful tendon disorder. It integrates current findings on cellular, molecular, and biomechanical mechanisms, highlighting how mechanical overload, inflammatory signals, and abnormal blood vessel behavior ...
Renate Gehwolf, Herbert Tempfer, Nevra Pelin Cesur, Andrea Wagner, Andreas Traweger, Christine Lehner   +5 more
wiley   +1 more source

The role of IP₃ receptors and SERCA pumps in restoring working memory under amyloid β induced Alzheimer's disease: a modeling study. [PDF]

Front Comput Neurosci
Huang Z, Wang L.
europepmc   +1 more source

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep

Advanced Science, EarlyView.
The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu, Na Zhang, Zilong Wen, Haitao Wang, Tingting Li, Runlin Ma, Menghua Li, Daxiang Wang, Haiping Shu, Xun Huang, Jianlin Han, Yiqiang Zhao, Qiuyue Liu   +12 more
wiley   +1 more source

Mechanistic insights into TTLL11 polyglutamylase-mediated primary tubulin chain elongation. [PDF]

Sci Adv
Campbell J, Vosahlikova M, Ismail S, Volnikova M, Motlova L, Kudlacova J, Ustinova K, Snajdr I, Novakova Z, Basta M, Gutsche I, Moutin MJ, Desfosses A, Barinka C.   +13 more
europepmc   +1 more source

Allosteric Effects in Nicotinamide Adenine Dinucleotide Phosphate-specific Glutamate Dehydrogenase from Neurospora

, 1967
David J. West, R. W. Tuveson, R. W. Barratt, J. R. S. Fincham   +3 more
openalex   +1 more source