Results 71 to 80 of about 70,807 (343)

Proton block of proton-activated TRPV1 current. [PDF]

, 2015
The TRPV1 cation channel is a polymodal nociceptor that is activated by heat and ligands such as capsaicin and is highly sensitive to changes in extracellular pH. In the body core, where temperature is usually stable and capsaicin is normally absent, H(+)
Lee, Bo Hyun, Zheng, Jie
core   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source

Biological Sources of Inflexibility in Brain and Behavior with Aging and Neurodegenerative Diseases

Frontiers in Systems Neuroscience, 2012
Almost unequivocally, aging and neurodegeneration lead to deficits in neural information processing. These declines are marked by increased neural noise that is associated with increased variability or inconsistency in behavioral patterns.
S. Lee eHong, George V. Rebec
doaj   +1 more source

Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824. [PDF]

, 2013
Background: Consolidated bioprocessing (CBP) is reliant on the simultaneous enzyme production, saccharification of biomass, and fermentation of released sugars into valuable products such as butanol. Clostridial species that produce butanol are, however,
Bolam, DN, Heap, JT, Jackson, A, Kovács, K, Minton, NP, Schwarz, K, Willson, BJ, Winzer, K   +7 more
core   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

A study of genetic heterogeneity in autism spectrum disorders based on plasma proteomic and metabolomic analysis: multiomics study of autism heterogeneity

MedComm, 2023
Genetic heterogeneity poses a challenge to research and clinical translation of autism spectrum disorder (ASD). In this study, we conducted a plasma proteomic and metabolomic study of children with ASD with and without risk genes (de novo mutation) and ...
Xiaoxiao Tang, Chengyun Feng, Yuxi Zhao, Huajie Zhang, Yan Gao, Xueshan Cao, Qi Hong, Jing Lin, Hongbin Zhuang, Yuying Feng, Hanghang Wang, Liming Shen   +11 more
doaj   +1 more source

PARP1 ADP-ribosylates lysine residues of the core histone tails [PDF]

, 2017
The chromatin-associated enzyme PARP1 has previously been suggested to ADP-ribosylate histones, but the specific ADP-ribose acceptor sites have remained enigmatic.
Altmeyer, Matthias, Caflisch, Amedeo, Gehrig, Peter, Hottiger, Michael O., Huang, Danzhi, Messner, Simon, Pozivil, Andrea, Roschitzki, Bernd, Rutishauser, Dorothea, Zhao, Hongtao   +9 more
core  

The synthesis and characterization of polypeptide-adriamycin conjugates and its complexes with adriamycin. Part I [PDF]

, 1985
Poly(α-l-glutamic acid) (PGA) was grafted with amino acid and oligopeptide spacers up to 5 amino acids with the use of N,N'-carbonyldiimidazole and 2,3-dihydro-1,2-benz-isothiazole-3-on-1, 1-dioxide (saccharin) as an additive, and these polypeptides were
Eenink, M.J.D., Feijen, J., Heeswijk, W.A.R., Hoes, C.J.T., Potman, W., Stoffer, T.   +5 more
core   +2 more sources

An Edible H2O2 Biosensor for Gastrointestinal Metabolites and Peroxidase Enzyme Quantification

Advanced Healthcare Materials, EarlyView.
We present an edible biosensor for gastric fluid analysis that integrates a caffeic acid–horseradish peroxidase redox system into an edible electrolyte‐gated transistor. The device enables rapid, low‐volume detection of H2O2 and, with minimal modification, metabolites and enzyme activity in simulated gastrointestinal conditions.
Valerio Francesco Annese, Elena Feltri, Pietro Rossi, Valerio Galli, Cristiano Bortolotti, João Paulo Vita Damasceno, Ivan K. Ilic, Dario Natali, Alessandro Luzio, Adrica Kyndiah, Mario Caironi   +10 more
wiley   +1 more source

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids

Journal of Lipid Research, 2013
Ubxd8, a multidomain protein sensor for long-chain unsaturated fatty acids (FAs), plays a crucial role to maintain cellular homeostasis of FAs. Ubxd8 polymerizes upon interaction with long-chain unsaturated FAs, but the molecular mechanism involved in ...
Hyeonwoo Kim, Hong Zhang, David Meng, Geoffrey Russell, Joon No Lee, Jin Ye   +5 more
doaj   +1 more source