Results 51 to 60 of about 9,376 (291)

Protein kinase C (PKC) phosphorylates the system N glutamine transporter SN1 (slc38a3) and regulates its membrane trafficking and degradation

Frontiers in Endocrinology, 2013
The system N transporter SN1 (also known as SNAT3) is enriched on perisynaptic astroglial cell membranes. SN1 mediates electroneutral and bidirectional glutamine transport, and regulates the intracellular as well as the extracellular concentrations of ...
Lise Sofie H. Nissen-Meyer, Farrukh Abbas Chaudhry   +1 more
doaj   +1 more source

Mutational and structural analyses of Caldanaerobius polysaccharolyticus Man5B reveal novel active site residues for family 5 glycoside hydrolases. [PDF]

PLoS ONE, 2013
CpMan5B is a glycoside hydrolase (GH) family 5 enzyme exhibiting both β-1,4-mannosidic and β-1,4-glucosidic cleavage activities. To provide insight into the amino acid residues that contribute to catalysis and substrate specificity, we solved the ...
Takuji Oyama, George E Schmitz, Dylan Dodd, Yejun Han, Alanna Burnett, Naoko Nagasawa, Roderick I Mackie, Haruki Nakamura, Kosuke Morikawa, Isaac Cann   +9 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Amantadine in the treatment of Pathological Gambling: a case report

Frontiers in Psychiatry, 2012
Despite almost a decade of intense research, effective treatment strategies for Pathological Gambling (PG) remain very challenging. This paper details a case report suggesting that the treatment of PG may benefit from the use of the non-specific ...
Mauro ePettorruso, Giovanni eMartinotti, Marco eDi Nicola, Marco eOnofrij, Gianluigi eConte, Massimo eDi Giannantonio, LUIGI eJANIRI   +6 more
doaj   +1 more source

Quantitative peptidomics of Purkinje cell degeneration mice. [PDF]

PLoS ONE, 2013
Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glutamates from tubulin. The Purkinje cell degeneration (pcd) mouse lacks CCP1 due to a mutation.
Iryna Berezniuk, Juan J Sironi, Jonathan Wardman, Raymond C Pasek, Nicolas F Berbari, Bradley K Yoder, Lloyd D Fricker   +6 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

AFM Study of Two-Dimensional Epitaxial Arrays of Poly(gamma-L-glutamates) with Long n-Alkyl Side Chains on Graphite

Two-dimensional (2D) arrays of poly(\ue7-n-alkyl L-glutamates) (PGn) on HOPG are found to be formed by casting under conditions producing submonolayer coverage. Direct observation of the arraysin a series of polymers using atomic force microscopy allowed
Imase T, Ohira A, Sano N, Watanabe J, Kawauchi S, Okoshi K, Kunitake M   +6 more
core   +5 more sources

Zn(OAc)2-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides

Molecules, 2018
Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time ...
Yanzhao Nie, Xinmei Zhi, Haifeng Du, Jing Yang   +3 more
doaj   +1 more source

Étude par absorption dipolaire de la transition hélice-chaîne de plusieurs poly-γ-glutamates de benzyle stéréoisomères en solvant binaire

, 2017
On donne les courbes de variation de la constante diélectrique lors de la transition hélice-chaîne de plusieurs poly-γ-glutamates de benzyle qui diffèrent par l’ordre dans lequel se succèdent les motifs D et L.
Claude Dufour, Gérard Spach, Eve Marchal   +2 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source