Results 31 to 40 of about 70,807 (343)

Obesity as a Limiting Factor for Remote Ischemic Postconditioning-Mediated Neuroprotection after Stroke

open access: yesJournal of Obesity & Metabolic Syndrome
Background : Remote ischemic postconditioning (RIPostC) may protect the brain from ischemia/reperfusion (I/R) injury. The association between RIPostC and obesity has not yet been extensively studied.
Klaudia Kotorová   +4 more
doaj   +1 more source

Synthesis of N -(4-propargylaminobenzoyl)-L-glutamates

open access: yesPteridines, 1994
To facilitate the rather labour consuming synthesis of antifolate γ-oligo-L-glutamates including those with the propargyl group at position N10 , two synthons possessing this group, α-t-butyl γ-methyl N-(4-propargylaminobenzoyl)- L-glutamate (1) and a-t ...
Kempny Michal   +2 more
doaj   +1 more source

Beyond Sulfate-Free Personal Cleansing Technology

open access: yesCosmetics
There is a strong global demand for sulfate-free personal cleansing products. The objective of sulfate-free personal cleansing technology should not be aimed solely at the absence of “sulfate” wording in the list of ingredients, but on the true benefits ...
Evelyn Su, Stephen Herman
doaj   +1 more source

Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases

open access: yesFrontiers in Molecular Neuroscience, 2022
The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and guanylyl cyclase B, have critical functions in many signaling pathways, but much remains unknown about their localization and function in vivo. To facilitate studies of
Jeremy R. Egbert   +13 more
doaj   +1 more source

Diversity of Fe2+ entry and oxidation in ferritins [PDF]

open access: yes, 2017
The essential metal iron presents two major problems for life: it is potentially highly toxic due to its redox activity, and its extremely low solubility in aqueous solution in the presence of O2 can make it hard to acquire and store safely.
Bradley, Justin M.   +2 more
core   +1 more source

Pharmacotherapy of Schizophrenia: Ploypharmacy Approaches [PDF]

open access: yesActa Medica Iranica, 2010
"nSchizophrenia is a debilitating illness, rating as one of the leading causes of lost years of quality of life. The illness imposes a disproportionate burden on patients and their families, healthcare systems and society. Pharmacological management
Fatemeh Rahiminejad, Shahin Akhondzadeh
doaj   +2 more sources

Identification of an osteocalcin isoform in fish with a large acidic prodomain [PDF]

open access: yes, 2014
Osteocalcin is a small, secreted bone protein whose gene consists of four exons. In the course of analyzing the structure of fish osteocalcin genes, we recently found that the spotted green pufferfish has two possible exon 2 structures, one of 15 bp and ...
Amores   +30 more
core   +1 more source

Expression and purification of recombinant vesicular glutamate transporter VGLUT1 using PC12 cells and High Five insect cells

open access: yesBiological Procedures Online, 2004
In synaptic vesicles, the estimated concentration of the excitatory amino acid glutamate is 100-150 mM. It was recently discovered that VGLUT1, previously characterized as an inorganic phosphate transporter (BNPI) with 9-11 predicted transmembrane ...
Andersen Søren S.L.
doaj   +1 more source

Transient expression in Nicotiana benthamiana for rapid functional analysis of genes involved in non-photochemical quenching and carotenoid biosynthesis. [PDF]

open access: yes, 2016
Plants must switch rapidly between light harvesting and photoprotection in response to environmental fluctuations in light intensity. This switch can lead to losses in absorbed energy usage, as photoprotective energy dissipation mechanisms can take ...
Erickson, Erika   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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