Results 131 to 140 of about 5,211,997 (349)

P450 Enzyme LyoI Performs Hydro‐2,2′‐Bifuran Oxidation in the Polyether Ionophore Lysocellin

open access: yesAngewandte Chemie, EarlyView.
In a study of the biosynthesis of the polyether ionophore lysocellin, the P450 enzyme LyoI was found to catalyze a rare oxidation of a hydro‐2,2′‐bifuran moiety to its hemiketal form. The oxidation was identified as the key for unlocking the bioactivity of lysocellin.
Michelle H. Rasmussen   +4 more
wiley   +2 more sources

The Mechanism and Potential Therapeutic Strategies of Vascular Aging

open access: yesAGING MEDICINE, EarlyView.
The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu   +4 more
wiley   +1 more source

Synthesis and Application of Bioactive N‐Functionalized Aziridines

open access: yesAngewandte Chemie, EarlyView.
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan   +4 more
wiley   +2 more sources

A Multi‐Stimuli‐Responsive Pd2L4 Metallacage for Amino Acid Sensing

open access: yesAggregate, EarlyView.
A multi‐stimuli‐responsive metallacage was constructed via a bottom‐up design strategy, and its stimuli‐responsive behaviors were investigated in response to basic/acidic reagents, naphthalene disulfonate, and thiol‐containing amino acids, accompanied by remarkable structural transformations and fluorescence variations.
Dongpu Wu   +7 more
wiley   +1 more source

Dendritic Pillar[6]Arenes with Fixed Planar Chirality for Stereoselective Inclusions in Water: A Case of Facile Differentiation of Cocaine Adulterants, Levamisole and Dexamisole

open access: yesAngewandte Chemie, EarlyView.
Dendritic pillar[6]arenes encompass a new class of cavitands with planar chirality, unique binding pockets, and great water solubility. These easily accessible hosts permit differentiating racemic dexamisole from levamisole as known cocaine adulterants.
Nitesh Kumar   +8 more
wiley   +2 more sources

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