Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali+7 more
wiley +1 more source
Biotin concentration affects anaplerotic reactions functioning in glutamic acid production in Corynebacterium glutamicum. [PDF]
Ochiai T, Wachi M, Hirasawa T.
europepmc +1 more source
CONFIGURATION OF THE CELLULAR GLUTAMIC ACID OF BACILLUS SUBTILIS
L Jenkins, Leon S. Ciereszko
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We present a biomimetic chloroplast system that integrates light‐dependent and light‐independent reactions, reaction compartments, and selectively permeable interfaces using a biphasic microfluidic droplet platform. This system enables continuous substrate–product exchange, mitigating product inhibition and side reactions, thus enhancing reaction ...
Guanxiong Wang+10 more
wiley +1 more source
Binding of Glutamic Acid to Silver and Gold Nanoparticles Investigated by Surface-Enhanced Raman Spectroscopy. [PDF]
Mohaček-Grošev V+6 more
europepmc +1 more source
Two new platinum‐binding peptides are identified by phage display against Pt‐{100} and polycrystalline targets. Binding free energies (ΔG) are quantified on Pt‐{111} surfaces using a quartz crystal microbalance with dissipation monitoring. Synchrotron radiation circular dichroism (SRCD) reveals facet‐dependent conformational adaptation on cubic (Pt ...
Monika Michaelis+3 more
wiley +1 more source
A Poly-γ-Glutamic Acid/ε-Polylysine Hydrogel: Synthesis, Characterization, and Its Role in Accelerated Wound Healing. [PDF]
Li J, Huang Y, Wang Y, Han Q.
europepmc +1 more source
Lanthanide‐Binding Lanmodulin‐Based Peptides: Insights from Advanced Mass Spectrometry Techniques
Analysis of lanthanide‐binding peptides in the gas phase by advances mass spectrometry methods saves sample amount and time. Selective peptide ligands for lanthanides (Ln) have multiple applications in, for example, Ln‐separation and recycling or as lanthanide‐binding tags.
Sophie M. Gutenthaler‐Tietze+2 more
wiley +1 more source
<i>Lachnospiraceae bacterium</i> alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway. [PDF]
Zhang H+17 more
europepmc +1 more source