Results 51 to 60 of about 253,703 (290)

Effect of the nitrogen source on glutamine and alanine biosynthesis in Neurospora crassa. An in vivo 15N nuclear magnetic resonance study [PDF]

, 1982
The influences of different nitrogen sources on the relative rates of biosynthesis of glutamine and alanine have been studied by 15N nuclear magnetic resonance spectroscopy of intact Neurospora crassa mycelia suspensions.
Kanamori, Keiko, Legerton, Timothy L., Roberts, John D., Weiss, Richard L.   +3 more
core  

Nanoparticles Combining Host‐Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum

Advanced Therapeutics, EarlyView.
This study investigates the combination of host‐directed therapeutics (HDT) with antibiotics in a single polymeric micelle based on polypept(o)ides for the therapy of Mycobacterium tuberculosis (Mtb) and ‐marinum (Mm) infections. When the HDT and antibiotic are co‐encapsulated, it significantly reduces bacterial burden in cells and improves overall ...
Gabriela Schäfer, Dongdong Bi, Federico Fenaroli, Andrew M. Thompson, Anno Saris, Matthias Barz   +5 more
wiley   +1 more source

Biosynthesis of Glutamic Acid [PDF]

, 1964
An unknown microorganism was isolated from the soil by using defined selective medium. It could synthesize glutamic acid from glucose and urea. When subjected to repeated ultra-violet light and X-ray irradiations, and after process of screening, the ...
Malin, Bernard, Tan, Wee Chong
core   +1 more source

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia, Kelley, Stephen P., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +3 more
core   +1 more source

Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy

Advanced Therapeutics, EarlyView.
Tuberculosis (TB) remains a global health challenge, with drug‐resistant strains exacerbating the issue. Metallic nanoparticles (MNPs) show promise in TB diagnosis as sensor probes and in combination therapy with antimycobacterial drugs, requiring further pre‐clinical and clinical research for clinical translation.
Christianah Aarinola Akinnawo, Admire Dube   +1 more
wiley   +1 more source

Comparison of Free Amino Acid Concentrations in Eosinophils and Neutrophils [PDF]

, 1985
Free amino acid concentrations were compared in eosinophils and neutrophils obtained from patients with eosinophilia. The level of glutamic acid was significantly higher in eosinophils than in neutrophils.
FUKUDA, Kiyotaka, USUI, Tomofusa
core  

Electrical Microneedles for Wound Treatment

Advanced Science, EarlyView.
A review on state‐of‐art research concerning electrical microneedles applied for wound treatment is presented. After a comprehensive analysis of mechanisms of electrical stimulation on wound healing, the derived three types of electrical microneedles are clarified and summarized. Further, their applications in wound healing are highlighted.
Yu Wang, Lijun Cai, Lu Fan, Li Wang, Feika Bian, Weijian Sun, Yuanjin Zhao   +6 more
wiley   +1 more source

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science, EarlyView.
RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
wiley   +1 more source

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu, Zicheng Yu, Yueping Liu, Lei Guo, Lianghong Teng, Lingchuan Guo, Li Liang, Jing Wang, Jie Gao, Ruiyu Li, Ling Yang, Xiu Nie, Dan Su, Zhiyong Liang   +13 more
wiley   +1 more source

Stochastic Photoresponse‐Driven Perovskite TRNGs for Secure Encryption Systems

Advanced Science, EarlyView.
This study presents a hybrid anionic polymer and perovskite TRNG generating 10 000 bits s−1, validated by NIST testing. Exceptional image encryption and implantable potential are demonstrated, highlighting advancements in portable and implantable security devices.
Dante Ahn, Minz Lee, Woochul Kim, Yeon Kyung Lee, Jun Young Lee, Gun Young Jung, Hangyeol Choi, Yohan Yoon, Hyun Seok Song, Heon Lee, Minah Seo, Jungwook Min, Yusin Pak   +12 more
wiley   +1 more source