Results 71 to 80 of about 274,636 (301)
Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells
Advanced Science, EarlyView.Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng +14 more
wiley +1 more source
Incorporation of Radioactive Glutamic Acid into the Proteins of Higher Plants [PDF]
, 1954 George C. Webster
openalex +1 more source
A Multi‐Property Optimizing Generative Adversarial Network for de novo Antimicrobial Peptide Design
Advanced Science, EarlyView.A Multi‐Property Optimizing Generative Adversarial Network (MPOGAN) is proposed to iteratively learn the relationship between peptides and multiple properties using a dynamically dataset. As the quality of the dataset improves, MPOGAN's ability to design antimicrobial peptides (AMPs) with multiple desired properties is enhanced.
Jiaming Liu +16 more
wiley +1 more source
The conversion of glucose into alanine and glutamic acid by rat liver, liver tumour and kidney in vivo [PDF]
, 1957 P.N. Campbell, June W. Halliday
openalex +1 more source
Advanced Science, EarlyView.Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo +7 more
wiley +1 more source
A modified glutamic acid dehydrogenase as a result of gene mutation in Neurospora crassa [PDF]
, 1957 J. R. S. Fincham
openalex +1 more source
Advanced Science, EarlyView.Arginine deficiency accelerates androgenetic alopecia. Serum metabolome shows reduced circulating arginine, while local metabolic disruption depletes follicular reserves, triggering reactive oxygen species (ROS) accumulation and mTOR suppression that induce hair miniaturization.
Shixin Duan +19 more
wiley +1 more source
Studies in Plant Metabolism. VI. Effect of 2,4-D on the Metabolism of Aspartic Acid and Glutamic Acid in the Bean Plant. [PDF]
, 1956 Thomas Jefferson Akers, S. C. Fang
openalex +1 more source
Biohybrid Computing with Proteinoids and Algae
Advanced Science, EarlyView.We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis +1 more
wiley +1 more source
Advanced Science, EarlyView.A bioluminescent probe, BLGLN, comprising BL568 and ASCT2‐uptaken AA201, enables real‐time monitoring and evaluation of ASCT2‐mediated glutamine uptake rates in living tumors via Staudinger ligation, aiding tumor metabolism studies and targeted therapeutics.
Bing‐Jun Zhou +9 more
wiley +1 more source