Results 81 to 90 of about 8,526,761 (285)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Cerebellar Ataxia and Glutamic Acid Decarboxylase Antibodies

JAMA Neurology, 2014
IMPORTANCE Current clinical and immunologic knowledge on cerebellar ataxia (CA) with glutamic acid decarboxylase 65 antibodies (GAD65-Abs) is based on case reports and small series with short-term follow-up data.
H. Ariño, N. Gresa-arribas, Y. Blanco, E. Martínez-Hernandez, L. Sabater, Mar Petit-Pedrol, I. Rouco, L. Bataller, J. Dalmau, A. Saiz, F. Graus   +10 more
semanticscholar   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

The Assimilation of Glutamic Acid by Yeast [PDF]

Journal of General Microbiology, 1949
SUMMARY: Using the corresponding amino-acid decarboxylases, the six amino-acids arginine, glutamic acid, histidine, lysine, ornithine and tyrosine were found to be free inside the cells of yeast. They are present when growth takes place in the absence of amino-acids, but their concentration may be increased by growing the organisms in media rich in ...
openaire   +2 more sources

Poly-glutamic acid reinforces wheat cadmium tolerance by modulating ascorbic acid and glutathione metabolism

We investigated the influence of poly-glutamic acid (PGA) on ascorbic acid (AsA) and glutathione (GSH) metabolism in leaves of wheat seedlings under cadmium (Cd) stress.
Ninghai Lu, Limin Wu, Qiumei Zhang
core   +1 more source

Thermodynamic Properties of 1-Propyl-3-methylimidazolium Glutamic Acid Salt

, 2010
Molar heat capacities (C(p.m)) of the room-temperature ionic liquid (IL) 1-propyl-3-methylimidazolium glutamic acid salt ([C(3)mim][Glu]) were measured with a high-precision automated adiabatic calorimeter (AC) in the temperature range of T = (85 to 360)
Zhao, Jun-Ning, Sun, Li-Xian, Tan, Zhi-Cheng, Tong, Jing, Liu, Qing-Shan, 谭志诚, Urs Welz-Biermann, Welz-Biermann, Urs   +7 more
core   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

A quadratic multinomial regression model was established for taste properties of main catechins and amino acid monomers in green tea

Shipin yu jixie
ObjectiveTo study the flavor intensity of green tea after mixing the main flavor monomers.MethodsThree main catechins [epigallocatechin gallate (EGCG), epigallocatechin gallate (GCG), epicatechin gallate (ECG)] and three amino acid monomers (aspartic ...
RAN Qiansong, LIU Zhongying, LIU Xi, HOU Yanshuang, BAO Fushu, PAN Ke   +5 more
doaj   +1 more source

Equilibrium of the solubility isotherm in systems Cobalt(II) chloride-glutamic acid-water [PDF]

E3S Web of Conferences
The study is focused on the interaction between glutamic acid and hexavodic cobalt chloride. The solubility curve, influenced by the high solubility of the initial components, extends horizontally along a catheter corresponding to the cobalt chloride ...
Aliev Togaymurot, Ernazarov Komil, Khusenov Kakhramon, Karimov Zokir, Kholikova Nazokat   +4 more
doaj   +1 more source