Results 171 to 180 of about 178,237 (260)

Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study. [PDF]

J Transl Med
Ding X, Zhang E, Huang Z, Li X, Wang Z, Wu Y, Liu C, Wu S.   +7 more
europepmc   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

Advanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou, Qingyuan Wu, Yang Wu, Runzhe Huang, Wei Li, Hanjie Niu, Hongtao Sun, Huiyu Liu   +7 more
wiley   +1 more source

Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and glutamine metabolism-associated gene. [PDF]

J Cardiothorac Surg
Wang S, Zheng M, Yang J.
europepmc   +1 more source

Enzyme‐Activated MRI for In Vivo Glucose Imaging via a Biodegradable Chromium Nanoprobe

Advanced Science, EarlyView.
Enzyme‐activated MRI (eaMRI) using a biodegradable CrGOx@Lip nanoprobe enables glucose‐specific imaging in vivo. GOx catalyzes glucose oxidation, triggering in situ formation of paramagnetic chromium gluconate and amplifying T1. This radiation‐free strategy maps tumor glucose uptake via the Warburg‐effect, quantifies hepatic glucose accumulation in ...
Yan Xu, Weitao Yang, Yanjing Yun, Hui Wang, Zhuoyao Wu, Youyi Yu, Bingbo Zhang   +6 more
wiley   +1 more source

Integrative Single-Cell and Machine Learning Analysis Develops a Glutamine Metabolism-Based Prognostic Model and Identifies MSMO1 as a Therapeutic Target in Osteosarcoma. [PDF]

Biomolecules
Ma H, Zhang H, Bajgai J, Rahman MH, Pham TT, Mo C, Cao B, Choi YE, Kim CS, Lee KJ.   +9 more
europepmc   +1 more source

Grape Seed Polyphenols Enhance Antioxidant Activity and Prolong the Lifespan of Caenorhabditis elegans Through SKN‐1/Nrf2 Pathway

AgriFood: Journal of Agricultural Products for Food, EarlyView.
GSP extends C. elegans lifespan, enhances stress resistance and reproduction, boosts antioxidant defenses (↑SOD/CAT/GSH‐Px, ↓ROS), remodels glycolysis/TCA/one‐carbon metabolism dose‐dependently, and activates SKN‐1/Nrf2 and H3K4 methylation—linking redox control to epigenetic modulation.
Boya Ouyang, Quanyong Wu, Fei Liu, Jingyimei Liang, Wanning Ma, Yuxuan Zhao, Hui Cao, Jianbo Xiao   +7 more
wiley   +1 more source

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells. [PDF]

EMBO J
Herrle N, Malacarne PF, Warwick T, Cabrera-Orefice A, Chen Y, Gheisari M, Chatterjee S, Leisegang MS, Sarakpi T, Wionski S, Lopez M, Kader C, Teichmann T, Drekolia MK, Koch I, Keßler M, Klein S, Erhard Uschner F, Trebicka J, Brunst S, Proschak E, Günther S, Rosas-Lemus M, Baumgarten N, Klatt S, Speer T, Bibli SI, Segarra M, Acker-Palmer A, Wagner JUG, Wittig I, Dimmeler S, Schulz MH, Richards JB, Gilsbach R, T Denton T, Fleming I, Hannibal L, Brandes RP, Rezende F.   +39 more
europepmc   +1 more source

Hybrid modeling for optimizing cell cultivation in mAb production using a small‐scale automated experimental platform

AIChE Journal, EarlyView.
Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto, Yuki Yoshiyama, Mizuki Morisasa, Junshin Iwabuchi, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama   +6 more
wiley   +1 more source