Results 181 to 190 of about 1,150,143 (287)

GSLR Drives Lung Adenocarcinoma as a Critical Regulator of Energy Homeostasis Through Creatine Kinase B Activation

Advanced Science, EarlyView.
This study identifies the glucose/glutamine sensitive lncRNA GSLR as a driver of lung adenocarcinoma progression. Nutrient restriction reduces chromatin accessibility at the GSLR locus and blocks CTCF‐mediated transcriptional regulation. GSLR directly interacts with DHX9 and recruits it to the CKB promoter, arresting R‐loop accumulation and promoting ...
Xinyi Qian, Juze Yang, Jiayi Ren, Xiaowei Mao, Jia Li, Tengfei Sun, Liangliang Dong, Enguo Chen, Yan Lu, Pengyuan Liu   +9 more
wiley   +1 more source

Targeting SLC1A5-mediated glutamine metabolism overcomes PARP inhibitor resistance in ovarian cancer. [PDF]

Cell Death Dis
Han F, Du H, Tian K, Qi G, Kong B, Luo X, Ma H.   +6 more
europepmc   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

PYCR1 promotes glutamine metabolism and the progression of lung adenocarcinoma by regulating the expression of OPLAH. [PDF]

Clin Exp Med
Chen W, Wang K, Wang R, Deng X, Liu X, Dai P, Liu Q.   +6 more
europepmc   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Corrigendum to "RUNX2 enhances bladder cancer progression by promoting glutamine metabolism" [Neoplasia 60 (2025) 101120, doi: 10.1016/j.neo.2024.101120]. [PDF]

Neoplasia
Huang Z, Liu B, Li X, Jin C, Hu Q, Zhao Z, Sun Y, Wang Q.   +7 more
europepmc   +1 more source

SLC25A4high Hepatocytes Enhance Lifestyle Intervention Response in MASLD by Recruiting Eating Macrophages

Advanced Science, EarlyView.
SLC25A4high hepatocytes drive metabolic‐associated steatotic liver disease (MASLD) remission by recruiting lipid‐eating macrophages. The hepatocyte Slc25a4/PANX1/ATP/P2ry12 axis mediates find‐me signaling that triggers macrophage recruitment and efferocytosis, while recruited macrophages secrete GDF15 to activate hepatocyte PPARα and promote fatty acid
Yiting Qian, Linying Lai, Yu Zhang, Yan Meng, Ziping Song, Baoyuan Huang, Guisheng Song, Bo Sun, Wenzhuo Yang   +8 more
wiley   +1 more source

Methionine metabolism is linked with phospholipid and glutamine metabolism to drive ferroptosis. [PDF]

Cell Rep
Kim JW, Jang SY, Roh YJ, Ju Y, Kang JB, Park BS, Lee JY, Kim MW, Jeong BJ, Jung W, Oh KJ, Kim WK, Han BS, Bae KH, Kim T, Kang YP, Yoo HM, Kim C, Dixon SJ, Choi DW, Hwang GS, Lee EW.   +21 more
europepmc   +1 more source

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

Advanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici, Mike Bismuth, Meir Goldsmith, Dan Peer, Tali Ilovitsh   +4 more
wiley   +1 more source

Glutamine metabolism as a rheostat of CD4⁺ T cell pathogenic function in metabolic dysfunction-associated steatotic liver disease. [PDF]

Cell Metab
Sawada K, Oates JR, Kimura M, Stankiewicz TE, Eom J, Alarcon PC, Chung H, Damen MSMA, Ulanowicz CJ, Wayland JL, Williams Fonner ESO, Anderson CC, Cuervo-Jimenez HK, Pearson AM, Wang Y, Salomonis N, Troutman TD, Reisz JA, Rathmell JC, Szabo S, Helmrath MA, Takebe T, Moreno-Fernandez ME, Divanovic S.   +23 more
europepmc   +1 more source