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Glutamine metabolism in metabolic acidosis.
Ciba Foundation symposium, 1982In chronic metabolic acidosis in the rat, there is increased ammoniagenesis, gluconeogenesis and renal extraction of glutamine with induction of renal phosphate-dependent glutaminase (PDG). Because the stimulus for these changes is not yet clear and also because acute acidosis is the more common clinical problem, the present study deals mainly with the
G A, Alleyne +6 more
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Beitrage zu Infusionstherapie und klinische Ernahrung, 1987
The outstanding role of glutamine in hepatic nitrogen metabolism in general has been the subject of extensive research within the past few years. Hepatic glutaminase shows an extraordinary pH sensitivity, is not inhibited by glutamate and is activated by its product ammonium, thereby contrasting the kidney enzyme.
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The outstanding role of glutamine in hepatic nitrogen metabolism in general has been the subject of extensive research within the past few years. Hepatic glutaminase shows an extraordinary pH sensitivity, is not inhibited by glutamate and is activated by its product ammonium, thereby contrasting the kidney enzyme.
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Glutamine metabolism drives PDAC
Science-Business eXchange, 2013Dana-Farber researchers have identified a glutamine metabolism pathway activated by oncogenic K-Ras in pancreatic cancers. The team found three different enzyme targets within the pathway that could be targeted to specifically inhibit tumor proliferation.
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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Glutamine Metabolism During Starvation
Journal of Parenteral and Enteral Nutrition, 1990N N, Abumrad +6 more
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Targeting cancer metabolism in the era of precision oncology
Nature Reviews Drug Discovery, 2021Zachary T Schug +2 more
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NAD+ metabolism and its roles in cellular processes during ageing
Nature Reviews Molecular Cell Biology, 2020Anthony J Covarrubias +2 more
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