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<i>CENPF</i> Promotes Gastric Cancer Proliferation through c-Myc-Mediated GLS1 Upregulation and Glutamine Metabolism. [PDF]
Oncol ResDong M, Song Z, Lu X, Lu M, Zhong C.
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Glutamine Metabolism in Cancer
Advances in Experimental Medicine and Biology, 2021 AbstractMetabolism is a fundamental process for all cellular functions. For decades, there has been growing evidence of a relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, cancer cells have reprogrammed metabolism in order to fulfill their energy requirements. These cells display crucial modifications
Anne Le
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Glutamine Metabolism in Brain Tumors [PDF]
Cancers, 2019 Altered metabolism is a hallmark of cancer cells. Tumor cells rewire their metabolism to support their uncontrolled proliferation by taking up nutrients from the microenvironment. The amino acid glutamine is a key nutrient that fuels biosynthetic processes including ATP generation, redox homeostasis, nucleotide, protein, and lipid synthesis.
Sriram Venneti, Siva Kumar Natarajan
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Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy
Trends in Cancer, 2021 Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as a promising target for cancer therapy. However, efforts to drug this process are confounded by the intrinsic metabolic heterogeneity and flexibility of tumors, as well
Wen-Hsuan Yang +2 more
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Glutamine Metabolism in Cancer
Advances in Experimental Medicine and Biology, 2018Metabolism is the fundamental process for all cellular functions. For decades, there has been growing evidence with regard to the relationship between metabolism and malignant cell proliferation. Unlike normal differentiated cells, however, cancer cells have reprogrammed metabolisms in order to fulfill their energy requirements.
Anne Le
exaly +3 more sources
Role of Glutamine and Interlinked Asparagine Metabolism in Vessel Formation [PDF]
EMBO Journal, 2017 Endothelial cell (EC) metabolism is emerging as a regulator of angiogenesis, but the precise role of glutamine metabolism in ECs is unknown. Here, we show that depriving ECs of glutamine or inhibiting glutaminase 1 (GLS1) caused vessel sprouting defects ...
Nadira Yuldasheva +2 more
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Journal of Parenteral and Enteral Nutrition, 1990
The role of the lungs in maintaining amino acid homeostasis has only recently been studied. The data suggest that the lungs play a key role in glutamine flow in both normal and catabolic states. Further studies are necessary to clarify the regulation of lung glutamine at the whole organ and cellular level.
W W, Souba, K, Herskowitz, D A, Plumley
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The role of the lungs in maintaining amino acid homeostasis has only recently been studied. The data suggest that the lungs play a key role in glutamine flow in both normal and catabolic states. Further studies are necessary to clarify the regulation of lung glutamine at the whole organ and cellular level.
W W, Souba, K, Herskowitz, D A, Plumley
openaire +2 more sources
Journal of Parenteral and Enteral Nutrition, 1990
The gut plays a key role in interorgan glutamine metabolism in normal and catabolic states. During critical illness, the gut responds to prevailing metabolic pressures that may result in a temporary "reset" in interorgan glutamine flow. As the body recovers from the disease process, the alterations in gut glutamine metabolism revert to normal, which ...
W W, Souba +4 more
openaire +2 more sources
The gut plays a key role in interorgan glutamine metabolism in normal and catabolic states. During critical illness, the gut responds to prevailing metabolic pressures that may result in a temporary "reset" in interorgan glutamine flow. As the body recovers from the disease process, the alterations in gut glutamine metabolism revert to normal, which ...
W W, Souba +4 more
openaire +2 more sources
Metabolism of glutamine in lymphocytes
Metabolism, 1989Pathways of glutamine metabolism in resting and proliferating rat thymocytes and established human T- and B-lymphoblastoid cell lines were evaluated by in vitro incubations of freshly prepared or cultured cells for one to two hours with [U14C]glutamine.
K, Brand +5 more
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Nutrition, 2002
Expression of high activities of both glutamine synthetase and glutaminase allows the liver to play a major role in the regulation of glutamine homeostasis. The liver shows net glutamine output in metabolic acidosis, in prolonged starvation and animals bearing tumors, net glutamine uptake in the postabsorptive state, on consuming high protein diets ...
Malcolm, Watford +4 more
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Expression of high activities of both glutamine synthetase and glutaminase allows the liver to play a major role in the regulation of glutamine homeostasis. The liver shows net glutamine output in metabolic acidosis, in prolonged starvation and animals bearing tumors, net glutamine uptake in the postabsorptive state, on consuming high protein diets ...
Malcolm, Watford +4 more
openaire +3 more sources