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Glutamine and Alanine Metabolism in NIDDM
Diabetes, 1996Gluconeogenesis is increased in NIDDM. We therefore examined the metabolism of glutamine and alanine, the most important gluconeogenic amino acids, in 14 postabsorptive NIDDM subjects and 18 nondiabetic volunteers using a combination of isotopic ([6-3H] glucose (20 µCi, 0.2 µCi/min), [U-14C]glutamine (20 µCi, 0.2 µCi/min), [3-13C]alanine (99% 13C, 2 ...
Michael Stumvoll +10 more
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Glutamine Metabolism in Gliomas
2016By histological, morphological criteria, and malignancy, brain tumors are classified by WHO into grades I (most benign) to IV (highly malignant), and gliomas are the most frequently occurring class throughout the grades. Similar to peripheral tumors, the growth of glia-derived tumor cells largely depends on glutamine (Gln), which is vividly taken up by
Monika, Szeliga, Jan, Albrecht
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Journal of Parenteral and Enteral Nutrition, 1990
A fundamental conceptional change in the field of hepatic glutamine metabolism is derived from an understanding of the unique regulatory properties of hepatic glutaminase, the occurrence of glutamine cycling, and the discovery of marked hepatocyte heterogeneities in nitrogen metabolism, with metabolic interactions between differently localized ...
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A fundamental conceptional change in the field of hepatic glutamine metabolism is derived from an understanding of the unique regulatory properties of hepatic glutaminase, the occurrence of glutamine cycling, and the discovery of marked hepatocyte heterogeneities in nitrogen metabolism, with metabolic interactions between differently localized ...
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Endotoxin and Renal Glutamine Metabolism
Archives of Surgery, 1991The effect of endotoxin on renal glutamine metabolism and ammoniagenesis was investigated in vivo in the rat to gain further insight into the altered glutamine flow that characterizes critical illness. Studies were done 15 hours following a single dose of Escherichia coli lipopolysaccharide (10 mg/kg).
T R, Austgen +3 more
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Glutamine metabolism and signaling in the liver
Frontiers in Bioscience, 2007Glutamine is the most abundant amino acid in the human body and can be synthesized by almost all tissues by the glutamine synthetase (GS)-catalyzed amidation of glutamate. Hepatocytes have access to extracellular glutamine by the concentrative uptake via members of the sodium-dependent neutral amino acid transport systems N and A.
Dieter, Häussinger, Freimut, Schliess
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Glutamine metabolism in human lymphocytes
Clinical Nutrition, 1990The data indicate that glutamine plays a critical role in the metabolism of human lymphocytes stimulated in vitro and in vivo. The understanding of these processes is a prerequisite if one is to substitute glutamine under conditions of compromised lymphocyte function.
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The metabolism of glutamine in the bovine lens: Glutamine as a source of glutamate
Experimental Eye Research, 1973Abstract The metabolism by the intact bovine lens of l -[ U - 14 C]glutamine has been studied and compared with that of l -[ U - 14 C]glutamate. [ 14 C]Glutamine was taken up and oxidized to 14 CO 2 at three times the rate of [ 14 C]glutamate. [ 14 C]Glutamine was largely converted to [ 14 C]glutamate, which was found in the lens in the free form,
P, Trayhurn, R, Van Heyningen
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Glutamine: A New Metabolic Substrate
1982Glutamine serves important metabolic functions in a variety of tissues, but it has only recently been recognized as a new component of the metabolism of bone-Glutamine and glutamate are present as free amino acids in bone water at concentrations 2.5 and 40 times greater than their respective concentrations in plasma. The mediated transport of glutamine
R M, Biltz +3 more
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Glutamine metabolism in metabolic acidosis.
Ciba Foundation symposium, 1982In chronic metabolic acidosis in the rat, there is increased ammoniagenesis, gluconeogenesis and renal extraction of glutamine with induction of renal phosphate-dependent glutaminase (PDG). Because the stimulus for these changes is not yet clear and also because acute acidosis is the more common clinical problem, the present study deals mainly with the
G A, Alleyne +6 more
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