Results 251 to 260 of about 1,091,861 (290)

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Hydrostatic pressure regulates glutamine metabolism to promote bladder fibroblast activation via the Piezo1/YAP1/GLS1 axis. [PDF]

J Transl Med
Li K, Wei P, Li Z, Kuang W, Zhang M, Luo C, Cui K, Lin D, Chen Z.   +8 more
europepmc   +1 more source

TGM2-P2RX7 loop promotes gemcitabine resistance in pancreatic cancer by modulating glutamine metabolism and mitophagy. [PDF]

Cell Death Discov
Ye K, Zhou S, Gong X, Zhu Z, Xiao M, Liang S.   +5 more
europepmc   +1 more source

‌PPIA regulates fatty acid and glutamine metabolism in lung adenocarcinoma based on multiomics prognostic model and experiment validation. [PDF]

Sci Rep
Gan Y, Wei W, Jiang B, Zhang X, Jiang L, Teng L, Xie X, Liu Y, Xie Q, Jiang L.   +9 more
europepmc   +1 more source

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Glutamine metabolism and signaling in the liver

Frontiers in Bioscience, 2007
Glutamine is the most abundant amino acid in the human body and can be synthesized by almost all tissues by the glutamine synthetase (GS)-catalyzed amidation of glutamate. Hepatocytes have access to extracellular glutamine by the concentrative uptake via members of the sodium-dependent neutral amino acid transport systems N and A.
Dieter, Häussinger, Freimut, Schliess
openaire   +2 more sources

Glutamine: A New Metabolic Substrate

1982
Glutamine serves important metabolic functions in a variety of tissues, but it has only recently been recognized as a new component of the metabolism of bone-Glutamine and glutamate are present as free amino acids in bone water at concentrations 2.5 and 40 times greater than their respective concentrations in plasma. The mediated transport of glutamine
R M, Biltz, J M, Letteri, E D, Pellegrino, L, Pinkus   +3 more
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Endotoxin and Renal Glutamine Metabolism

Archives of Surgery, 1991
The effect of endotoxin on renal glutamine metabolism and ammoniagenesis was investigated in vivo in the rat to gain further insight into the altered glutamine flow that characterizes critical illness. Studies were done 15 hours following a single dose of Escherichia coli lipopolysaccharide (10 mg/kg).
T R, Austgen, M K, Chen, W, Moore, W W, Souba   +3 more
openaire   +2 more sources

Glutamine metabolism in human lymphocytes

Clinical Nutrition, 1990
The data indicate that glutamine plays a critical role in the metabolism of human lymphocytes stimulated in vitro and in vivo. The understanding of these processes is a prerequisite if one is to substitute glutamine under conditions of compromised lymphocyte function.
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The metabolism of glutamine in the bovine lens: Glutamine as a source of glutamate

Experimental Eye Research, 1973
Abstract The metabolism by the intact bovine lens of l -[ U - 14 C]glutamine has been studied and compared with that of l -[ U - 14 C]glutamate. [ 14 C]Glutamine was taken up and oxidized to 14 CO 2 at three times the rate of [ 14 C]glutamate. [ 14 C]Glutamine was largely converted to [ 14 C]glutamate, which was found in the lens in the free form,
P, Trayhurn, R, Van Heyningen
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Glutamine metabolism in metabolic acidosis.

Ciba Foundation symposium, 1982
In chronic metabolic acidosis in the rat, there is increased ammoniagenesis, gluconeogenesis and renal extraction of glutamine with induction of renal phosphate-dependent glutaminase (PDG). Because the stimulus for these changes is not yet clear and also because acute acidosis is the more common clinical problem, the present study deals mainly with the
G A, Alleyne, J A, Lupianez, N, McFarlane-Anderson, P, Hortelano, J, Benjamin, J, Barnswell, B, Scott   +6 more
openaire   +1 more source