Results 211 to 220 of about 184,210 (258)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +1 more source

Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study. [PDF]

J Transl Med
Ding X, Zhang E, Huang Z, Li X, Wang Z, Wu Y, Liu C, Wu S.   +7 more
europepmc   +1 more source

Mitochondrial Glutamine Metabolism Drives Epileptogenesis in Primary Hippocampal Neurons. [PDF]

J Neurosci
Kubista H, Gentile F, Schicker K, Köcher T, Boehm S, Hotka M.   +5 more
europepmc   +1 more source

Reprogramming glutamine metabolism enhances BCMA-CAR T-cell fitness and therapeutic efficacy in multiple myeloma.

Blood
Navarro F, Lozano T, Fuentes-García A, Sánchez-Moreno I, Larrayoz M, Justicia P, Perucha B, Martinez-Tabar M, Martinez-Turrillas R, Casares N, Martín-Otal C, Gorraiz M, Meermeier EW, Chesi M, Lake D, Bergsagel PL, Santamaría E, Calleja-Cervantes ME, San Martín-Uriz P, Jordana-Urriza L, Agirre X, Hervás-Stubbs S, Rodriguez-Madoz JR, Martinez-Climent JÁ, Prosper F, Lasarte JJ.   +25 more
europepmc   +1 more source

Sericin Enhances Cryopreserved Sperm Quality in Chengde Hornless Black Goats by Increasing Glutamine Metabolism. [PDF]

Animals (Basel)
Yu Y, Xia W, Zhang W, Tao C, Tian X, Li M, Zhang X, Zhang J, Zhao S, Qi Y, Qin T, Li J.   +11 more
europepmc   +1 more source

Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and glutamine metabolism-associated gene. [PDF]

J Cardiothorac Surg
Wang S, Zheng M, Yang J.
europepmc   +1 more source

Integrative Single-Cell and Machine Learning Analysis Develops a Glutamine Metabolism-Based Prognostic Model and Identifies MSMO1 as a Therapeutic Target in Osteosarcoma. [PDF]

Biomolecules
Ma H, Zhang H, Bajgai J, Rahman MH, Pham TT, Mo C, Cao B, Choi YE, Kim CS, Lee KJ.   +9 more
europepmc   +1 more source

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells. [PDF]

EMBO J
Herrle N, Malacarne PF, Warwick T, Cabrera-Orefice A, Chen Y, Gheisari M, Chatterjee S, Leisegang MS, Sarakpi T, Wionski S, Lopez M, Kader C, Teichmann T, Drekolia MK, Koch I, Keßler M, Klein S, Erhard Uschner F, Trebicka J, Brunst S, Proschak E, Günther S, Rosas-Lemus M, Baumgarten N, Klatt S, Speer T, Bibli SI, Segarra M, Acker-Palmer A, Wagner JUG, Wittig I, Dimmeler S, Schulz MH, Richards JB, Gilsbach R, T Denton T, Fleming I, Hannibal L, Brandes RP, Rezende F.   +39 more
europepmc   +1 more source

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Response of glutamine metabolism to exogenous glutamine in humans

American Journal of Physiology-Endocrinology and Metabolism, 1995
To determine whether exogenous glutamine affects whole body glutamine metabolism, preliminary experiments were performed to verify that L-[1-13C]-, L-[U-14C]-, and L-[3,4-3H]glutamine given simultaneously by vein provided similar estimates of glutamine appearance rates [Ra; 355 +/- 24, 373 +/- 19, and 393 +/- 24 (SE) mumol.kg-1.h-1, respectively, P ...
R G, Hankard, D, Darmaun, B K, Sager, D, D'Amore, W R, Parsons, M, Haymond   +5 more
openaire   +2 more sources