Results 121 to 130 of about 78,410 (212)

⁠⁠Functional Foods Alleviate Behavioral Alterations and Improve GABAergic System Regulating TLR‐4/NF‐κB Axis in Valproic‐Induced Autism

Brain and Behavior, Volume 15, Issue 6, June 2025.
Dietary supplementation with Coriolus versicolor ameliorate neuroinflammation VPA‐induced. ABSTRACT Scope Valproic acid (VPA) postnatal exposure in mice results in behavioral impairment, aberrant sensitivity to sensory stimuli, and self‐harming behavior, hallmarks of autism.
Francesco Molinari, Roberta Fusco, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Ali S. Abdelhameed, Tilman Fritsch, Ursula M. Jacob, Salvatore Cuzzocrea, Vittorio Calabrese, Rosanna Di Paola, Marika Cordaro   +11 more
wiley   +1 more source

Distinct evolution of type I glutamine synthetase in Plasmodium and its species-specific requirement. [PDF]

Nat Commun, 2023
Ghosh S, Kundu R, Chandana M, Das R, Anand A, Beura S, Bobde RC, Jain V, Prabhu SR, Behera PK, Mohanty AK, Chakrapani M, Satyamoorthy K, Suryawanshi AR, Dixit A, Padmanaban G, Nagaraj VA.   +16 more
europepmc   +1 more source

The Essentiality of Amino Acids in Healthiness and Disease State: Type II Diabetes as a Case Study

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This review investigates the functions of amino acids in normal physiological states, their potential as a diagnostic biomarker, the probable risk of deficiency, and the therapeutic ability for managing and preventing type 2 diabetes mellitus. ABSTRACT A healthy life depends on the availability and the synthesis of amino acids as they are building ...
Samuel Idowu Fayomi, Ochuko Lucky Erukainure, Nontokozo Zimbili Msomi   +2 more
wiley   +1 more source

Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1^-/- mice. [PDF]

iScience, 2023
Wang J, Gao Y, Xiao L, Lin Y, Huang L, Chen J, Liang G, Li W, Yi W, Lao J, Zhang B, Gao TM, Zhong M, Yang X.   +13 more
europepmc   +1 more source

Optimal Selenium Fertilizer Affects the Formation of Foxtail Millet (Setaria italica L.) Quality by Regulating Flavonoid Metabolism and Amino Acid Metabolism

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
S2 treatment regulated the flavonoid and histidine metabolism pathways of Jingu 21, reduced the protein content, increased the fat and starch contents, and decreased the peak viscosity and breakdown value. S2 treatment regulated the Stilbenoid, diarylheptanoid, and gingerol pathway of Jingu 40, and S3 treatment activated the tyrosine metabolic pathway ...
Shu Wang, Jiao Mao, Yuanmeng Xu, Sichen Liu, Zhijun Qiao, Xiaoning Cao   +5 more
wiley   +1 more source

Loss of Müller cell glutamine synthetase immunoreactivity is associated with neuronal changes in late-stage retinal degeneration. [PDF]

Front Neuroanat, 2023
Reynisson H, Kalloniatis M, Fletcher EL, Shivdasani MN, Nivison-Smith L.   +4 more
europepmc   +1 more source

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

Glia, Volume 73, Issue 6, Page 1166-1187, June 2025.
Main Points Generation and characterization of iPSC‐derived astrocytes from 44 aged humans. Congruence of gene expression profiles between astrocyte cultures and brain. Association of interferon response proteins with AD pathology resilience. ABSTRACT Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants
Hyo Lee, Richard V. Pearse II, Alexandra M. Lish, Cheryl Pan, Zachary M. Augur, Gizem Terzioglu, Pallavi Gaur, Meichen Liao, Masashi Fujita, Earvin S. Tio, Duc M. Duong, Daniel Felsky, Nicholas T. Seyfried, Vilas Menon, David A. Bennett, Philip L. De Jager, Tracy L. Young‐Pearse   +16 more
wiley   +1 more source

Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example

iMeta, Volume 4, Issue 3, June 2025.
We present an innovative methodology that integrates core enzyme identification, protein structural characterization, regulator virtual screening, and functional validation to achieve precise microbiome functional regulation. As a proof of concept, we focused on the regulation of urea decomposition by the rumen microbiota in ruminants. This methodology
Shengguo Zhao, Huiyue Zhong, Yue He, Xiaojiao Li, Li Zhu, Zhanbo Xiong, Xiaoyin Zhang, Nan Zheng, Diego P. Morgavi, Jiaqi Wang   +9 more
wiley   +1 more source

Hepatic glutamine synthetase controls N⁵-methylglutamine in homeostasis and cancer. [PDF]

Nat Chem Biol, 2023
Villar VH, Allega MF, Deshmukh R, Ackermann T, Nakasone MA, Vande Voorde J, Drake TM, Oetjen J, Bloom A, Nixon C, Müller M, May S, Tan EH, Vereecke L, Jans M, Blancke G, Murphy DJ, Huang DT, Lewis DY, Bird TG, Sansom OJ, Blyth K, Sumpton D, Tardito S.   +23 more
europepmc   +1 more source

Age‐specific reference intervals for plasma amino acids and their associations with nutrient intake in the Chinese pediatric population

iMeta, Volume 4, Issue 3, June 2025.
A total of 2901 healthy Chinese children aged 0–12 years were enrolled in the reference group; 102 confirmed Phenylketonuria cases were included as validation individuals. Establishing the age‐specific reference intervals of 42 plasma amino acids in Chinese pediatric populations. Profiling dynamic interactions between multiple nutrient intake and amino
Yang Wen, Qing Liu, Hongbo Zeng, Lina Lyu, Xuezhen He, Xin Zhang, Wentao Lyu, Weijun Chen, Yingping Xiao   +8 more
wiley   +1 more source