Results 121 to 130 of about 87,161 (272)

Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis

Cell Reports
Summary: Glutamine homeostasis plays a crucial role in fundamental cellular processes and is often dysregulated in cancer cells; however, the underlying mechanisms governing this homeostasis remain unclear.
Siyi Li, Ting Ling, Yuhan Wang, Jing Shi, Qiuping Wang, Jing Lv, Jinghan Li, Yu Liu, Yi Zhang, Changhao Liu, Tian Xia, Di Chen, Wenqi Wang, Hong-Xu Liu, Hai-long Piao   +14 more
doaj   +1 more source

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Sporadic Hepatocellular Carcinoma in an Adolescent Harboring a Somatic CDH1 Mutation: A Case Report and Literature Review

The Kaohsiung Journal of Medical Sciences, EarlyView.
Chang‐Wei Su, Peir‐In Liang, Shih‐Chang Chuang   +2 more
wiley   +1 more source

High‐throughput multispecies quantitative polymerase chain reaction assays to study the effects of acute thermal stress in three species of Acipenser sturgeon

Journal of Fish Biology, EarlyView.
Abstract Fishes experience thermal stress in their natural environment that can be caused by natural or anthropogenic factors and can directly affect their physiology. In this study, we developed a multispecies OpenArray™ qPCR (quantitative polymerase chain reaction) ‘chip’ to measure the effects of acute thermal stress on the mRNA response of ...
Hossein Haghighi, Kyle Madden, William S. Bugg, Faith M. Penny, Scott A. Pavey, Nicholas J. Bernier, Kenneth M. Jeffries   +6 more
wiley   +1 more source

Streamlined rAAV HeLaS3 producer cell line generation via GS selection

Scientific Reports
The high cost and complexity of manufacturing recombinant adeno-associated virus vectors continue to limit the broader application of gene therapies, which offer life-changing potential for individuals affected by genetic diseases.
Mariana Antunes, Filipa Moura, Ivy Rose Sebastian, Paula Alves, Patrícia Gomes-Alves, Jose M. Escandell   +5 more
doaj   +1 more source

The Efficacy of Food‐Grade Substances to Protect Dietary Glutamine From Ruminal Degradation

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study was conducted to investigate the use of four, low cost, food‐grade substances to protect glutamine from microbial degradation in vitro, and subsequently validate their efficacy in vivo. Two in vitro trials were conducted using 250 mL bottles replicated in triplicate to test beeswax‐, paraffin wax‐, zein‐, and rice bran wax ...
Lillian P. Carlyon, Tianna R. Boyce, Leesa‐Joy Dunstan, Bruno R. C. Alves, Kiro Petrovski, Mariana Caetano   +5 more
wiley   +1 more source

Glutamine metabolism, a double agent combating or fuelling hepatocellular carcinomaKey points

JHEP Reports
Summary: The reprogramming of glutamine metabolism is a key event in cancer more generally and in hepatocellular carcinoma (HCC) in particular. Glutamine consumption supplies tumours with ATP and metabolites through anaplerosis of the tricarboxylic acid ...
Razan Abou Ziki, Sabine Colnot
doaj   +1 more source

Phenylalanine 15N enrichment likely indicates fungal‐derived organic nutrient acquisition in mycoheterotrophic plants across fungal guilds

New Phytologist, EarlyView.
Summary Beyond fully mycoheterotrophic plants, many green plants may also obtain carbon from fungal partners. However, bulk stable isotope analyses often lack sufficient resolution in arbuscular mycorrhizal and rhizoctonia‐associated orchid systems, limiting inference of fungal‐derived organic nutrient acquisition.
Kenji Suetsugu, Chikage Yoshimizu, Jun Matsubayashi, Ichiro Tayasu   +3 more
wiley   +1 more source

Heat‐evolved coral photosymbionts exhibit dampened stress responses across distinct physiological contexts

New Phytologist, EarlyView.
Summary Experimental evolution under elevated temperatures has generated heat‐evolved (HE) strains of Symbiodiniaceae that enhance coral bleaching tolerance. However, the biomolecular mechanisms underlying this resilience remain poorly understood. We conducted a laboratory heat‐stress experiment and applied synchrotron‐based Fourier transform infrared (
Bede G. Johnston, Madeline R. Garing, Annaleise R. Klein, Wing Yan Chan, Matthew R. Nitschke, Madeleine J. H. van Oppen   +5 more
wiley   +1 more source