Results 71 to 80 of about 16,021,849 (210)
Arquivos de Gastroenterologia, 2006 RACIONAL: O fenobarbital é utilizado em modelos experimentais não só por ser um importante agente promotor da carcinogênese em fígado de ratos, como também por ser não-genotóxico, órgão-específico e dose-dependente.
Helena Terezinha Hubert Silva +1 more
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Characterization of Glutathione S-Transferase in Cultured Human Keratinocytes
, 1991 The glutathione S-transferase activity and isozymic composition of cultured human keratinocytes were characterized. Keratinocytes were grown in culture and harvested at different stages of differentiation.
Boyer, Thomas D +3 more
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Urinary glutathione-S-transferase in cisplatin nephrotoxicity in the rat [PDF]
, 1986 Summary: Rats given a single toxic dose of cisplatin all developed detectable glutathione-S-transferase activity in their urine between the third and fifth day after injection of cisplatin, simultaneously with the decreased urine osmplality and increased
V. L. Fuh +5 more
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Selective inhibition of oat glutathione-S-transferase activity by tetrapyrroles
, 1988 Inhibition of glutathione-S-transferase activity by various tetrapyrroles (bilirubin, biliverdin, chlorophyllin and hemin) has been studied. Addition of 77 μM bilirubin or biliverdin inhibited glutathione-S-transferase activity only by 15–19% whereas ...
Bal Ram Singh +3 more
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Brazilian Journal of Medical and Biological Research, 2003 Changes in glutathione levels were determined in tissues of 11- to 12-week-old Swiss albino mice at different stages of Dalton's lymphoma tumor growth and following cisplatin (8 mg/kg body weight, ip) treatment for 24-96 h, keeping 4-5 animals in each ...
Khynriam D., Prasad S.B.
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The Bisulphite-Sequencing PCR for the Bovine Gstp1, Gsta4, and Ache Gene Methylation Study
Folia VeterinariaModifying cytosine by adding a methyl group in CpG dinucleotides within DNA sequence has several functions, but acts primarily as an important regulatory mechanism of mammalian gene expression.
Halušková Jana +4 more
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, 1997 Glutathione S-transferases are involved in the detoxification of reactive electrophilic compounds, including intracellular metabolites, drugs, pollutants and pesticides. A cluster of three glutathione S-transferase genes, designated GSTA, GSTA1 and GSTA2,
George, Stephen +2 more
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, 2000 The glutathione S-transferase (GST) family of enzymes function in the body to detoxify carcinogenic compounds. Several genes that code for these enzymes are polymorphic, with particular genotypes previously shown to confer an increased cancer risk.
Curran, Joanne +7 more
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Expression of Glutathione S-transferase-pi (GST-pi)and Metallothionein (MT)in Lung Cancer
, 1997 細胞内解毒酵素であるグルタチオンS一トランスフェラーゼπ(GST一π)やメタロチオネイン(MT)が癌細胞の抗癌剤耐性に関与していることが実験的に示唆されている.本研究では, GST一πとMTの発現を手術肺癌97例で免疫組織染色にて分析し, 化学療法との関係を検討した.GST一πは未治療の非小細胞肺癌56例て86%陽性と小細胞肺癌より有意に発現が高かった ...
岡, 三喜男 +9 more
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Genetics and Molecular Biology, 2009 Exposure to benzene has been associated with haematological diseases such as neutropenia (NEB) and acute myeloid leukaemia (AML). We tested whether the null genotypes of the GSTM1 and GSTT1 genes, involved in benzene inactivation, altered the risk for ...
Carmen Silvia Passos Lima +5 more
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