Results 141 to 150 of about 775,294 (358)

Hypermethylation of GSTM5 and its effect on oxidation in myelodysplastic syndrome

iLABMED
Background Hypermethylation of glutathione‐S‐transferase 5 (GSTM5) and its effect on oxidation in the pathogenesis of myelodysplastic syndrome (MDS) were investigated.
Chi Wang, Yafei Yu, Qing Chang, Tengteng Dong, Liye Wang, Mianyang Li   +5 more
doaj   +1 more source

Glutathione-Depleting Pro-Oxidant as a Selective Anticancer Therapeutic Agent

, 2019
A main challenge in the development of anticancer drugs that eradicate cancer cells specifically with minimal toxicity to normal cells is to identify the cancer-specific properties. Cancer cells sustain a higher level of reactive oxygen species, owing to
Hyejin Hyun, Dongin Kim, Joungyoun Noh (5962928), Hyejin Hyun (6205106), Dongin Kim (2002045), Seri Hong, Donghyuck Yoo (3768778), Eunkyeong Jung (4728066), Dongwon Lee (239125), Eunkyeong Jung, Joungyoun Noh, Semee Seon (6817211), Seri Hong (696225), Dongwon Lee, Donghyuck Yoo, Semee Seon   +15 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Platinum Nanoparticles Loaded in Polydopamine-Modified Porous Coordination Network-224 with Peroxidase-Like Activity for Sensitive Glutathione Detection

Biomolecules
The content of glutathione in the human body is crucial to human health, so a convenient and efficient method is needed to detect it. Herein, porous coordination network-224 (PCN-224) was modified by polydopamine to prepare polydopamine-modified PCN-224 (
Shoubei Gao, Mingyue Gao, Chenran Zhen, Yanshuai Cui, Xianbing Ji, Ruyu Li, Longgang Wang   +6 more
doaj   +1 more source

The glutathione biosynthesis in the psychrophile Pseudoalteromonas haloplanktis

, 2011
Reduced glutathione (GSH), together with its oxidized form (GSSG), is the most effective antioxidant system responsible for controlling the cellular redox state. Its biosynthesis from glutamate, cysteine and glycine, normally requires two enzymes. Indeed,
Albino, Antonella
core  

Efeitos da exposição aguda ao selênio e ao cobre sobre as defesas antioxidantes de mexilhões marinhos Perna perna [PDF]

, 2010
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Embora muitos metais, como o cobre, sejam essenciais para os organismos, o seu uso industrial e na agricultura tem levado a um aumento de sua concentração na
Silva, Marcella Uliano da
core  

Metabolism and toxicity of two new benzodiazepine-type antileishmanial agents in hepatocytes and macrophages

, 2007
With increasing reports of resistance of Leishmania to antimonials (Thakur et al., 2004) and other traditional antileishmanial drugs, the need for the discovery of new antileishmanial agents is rising.
Mullen, A.B., Grant, M.H., Mackay, S.P., Tettey, J.N.A., Duong Thi, M.D., Clarke, R.   +5 more
core   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Toxicity induced by Solanapyrone A in Chickpea shoots and its metabolism through Glutathione/Glutathione-S-Transferase system

, 2013
Solanapyrone A and C were isolated from a Pakistani isolate of Ascochyta rabiei, Pk-1. Two experiments were conducted to investigate the phytotoxic effects of the most potent toxin, solanapyrone A on chickpea cultivars and its subsequent detoxification ...
Riaz, A., Naz, F., Abdur Rauf, C., Qadir, G., Haque, I., Nicklin, Jane   +5 more
core  

Versatility of Glutathione Transferase Proteins

Glutathione transferases are abundant enzymes in various aerobic organisms in which they provide cellular protection against reactive compounds that cause mutations and cancer. Their evolution may have been a response to oxidative stress caused by oxygen

core   +1 more source