Results 281 to 290 of about 986,817 (390)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Mitochondria and Aging: Redox Balance Modulation as a New Approach to the Development of Innovative Geroprotectors (Fundamental and Applied Aspects). [PDF]

Int J Mol Sci
Mironova E, Kvetnoy I, Balazovskaia S, Antonov V, Poyarkov S, Mazzoccoli G.   +5 more
europepmc   +1 more source

Growth Regulating Substances in Extracts of Maple and Pear Flower Buds [PDF]

, 1958
Bailey, Lowell F., Tackett, Dewey L.
core   +2 more sources

Evaluation of Biochemical Marker - Glutathione and DNA Fingerprinting of Biofield Energy Treated Oryza sativa

, 2015
Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Nayak, Gopal, Sambhu Charan Mondal, Snehasis Jana   +5 more
openalex   +2 more sources

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Redox Modulation in Therapy of Cancer: Some Pros and Cons. [PDF]

Antioxidants (Basel)
Zorova LD, Semenovich DS, Zorov SD, Oleynikov IP, Kargapoltceva AS, Prutskikh DV, Abramicheva PA, Pevzner IB, Sukhikh GT, Zorov DB.   +9 more
europepmc   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Application of silicon and gibberellic acid modulate photosynthetic capacity and antioxidative defense machinery in Saccharum officinarum cv. GT55. [PDF]

Sci Rep
Fan YG, Verma KK, Chen RF, Li YR, Song XP, Zhang YB, Guo JW, Que YX, Wu ZM, Deng YC, Wu JM.   +10 more
europepmc   +1 more source

Characterization of Glutathione S-Transferase of Taenia solium

, 1999
Norberto Vibanco‐Pérez, L. Jiménez, Marie Thêrese Merchant, A Landa   +3 more
openalex   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source