Results 261 to 270 of about 569,398 (304)
Some of the next articles are maybe not open access.
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Glutathione (GSH) is synthesized in the cytoplasm but there is a requirement for glutathione not only in the cytoplasm, but in the other organelles and the extracellular milieu. GSH is also imported into the cytoplasm. The transports of glutathione across these different membranes in different systems have been biochemically demonstrated.
Anand K, Bachhawat +3 more
openaire +2 more sources
Glutathione (GSH) is synthesized in the cytoplasm but there is a requirement for glutathione not only in the cytoplasm, but in the other organelles and the extracellular milieu. GSH is also imported into the cytoplasm. The transports of glutathione across these different membranes in different systems have been biochemically demonstrated.
Anand K, Bachhawat +3 more
openaire +2 more sources
Antioxidants & Redox Signaling, 2017
Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
openaire +2 more sources
Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
openaire +2 more sources
[Glutathione and glutathione assays].
Acta medica (Hradec Kralove). Supplementum, 2006Glutathione, the very important intracellular antioxidant, is present in intracelullar environment in milimolar concentrations. Glutathione is a tripeptide molecule, which plays an essential role in the antioxidant system, as well as in maintenance of the intracellular redox state.
Tomás, Rousar +5 more
openaire +1 more source
Detoxication reactions of glutathione and glutathione transferases
Xenobiotica, 1986(1986). Detoxication reactions of glutathione and glutathione transferases. Xenobiotica: Vol. 16, No. 10-11, pp. 957-973.
openaire +2 more sources
Glutathione and detoxification
Cancer Treatment Reviews, 1990Cisplatin is recognized as one of the most effective drugs in the treatment of a variety of solid tumors. Its therapeutic usefulness has been limited by acute and cumulative nephrotoxicity ( 13). This side-effect is dose-dependent and requires adequate protective measures.
M, Tedeschi +6 more
openaire +2 more sources
Analytical Biochemistry, 1980
Abstract The total glutathione content of biological samples is conveniently determined with an enzymatic recycling assay based on glutathione reductase ( F. Tietze, 1969 , Anal. Biochem. 27 , 502–522). In the original and several subsequent descriptions of this procedure, glutathione disulfide is selectively determined by assaying samples in which
openaire +2 more sources
Abstract The total glutathione content of biological samples is conveniently determined with an enzymatic recycling assay based on glutathione reductase ( F. Tietze, 1969 , Anal. Biochem. 27 , 502–522). In the original and several subsequent descriptions of this procedure, glutathione disulfide is selectively determined by assaying samples in which
openaire +2 more sources
Biochemistry (Moscow), 2007
Many functions of mitochondrial GSH are significantly different from those of cytosolic GSH. This review considers the peculiarity of functions of mitochondrial GSH and enzymes of its metabolism, especially glutathione peroxidase 4, glutaredoxin 2, and kappa-glutathione transferase.
V I, Kulinsky, L S, Kolesnichenko
openaire +2 more sources
Many functions of mitochondrial GSH are significantly different from those of cytosolic GSH. This review considers the peculiarity of functions of mitochondrial GSH and enzymes of its metabolism, especially glutathione peroxidase 4, glutaredoxin 2, and kappa-glutathione transferase.
V I, Kulinsky, L S, Kolesnichenko
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Glutathione (GSH) is a linchpin of cellular defences in plants and animals with physiologically-important roles in the protection of cells from biotic and abiotic stresses. Moreover, glutathione participates in numerous metabolic and cell signalling processes including protein synthesis and amino acid transport, DNA repair and the control of cell ...
José Luis, García-Giménez +6 more
openaire +2 more sources
Glutathione (GSH) is a linchpin of cellular defences in plants and animals with physiologically-important roles in the protection of cells from biotic and abiotic stresses. Moreover, glutathione participates in numerous metabolic and cell signalling processes including protein synthesis and amino acid transport, DNA repair and the control of cell ...
José Luis, García-Giménez +6 more
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has demonstrated protective abilities against the detrimental effects of oxidative stress within the human body, as well as protection against infection by exogenous microbial organisms.In this review we describe how GSH works to modulate the behavior of many cells including the cells of ...
Devin, Morris +8 more
openaire +2 more sources
The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has demonstrated protective abilities against the detrimental effects of oxidative stress within the human body, as well as protection against infection by exogenous microbial organisms.In this review we describe how GSH works to modulate the behavior of many cells including the cells of ...
Devin, Morris +8 more
openaire +2 more sources
Current Opinion in Clinical Nutrition and Metabolic Care, 2001
Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases. However, whether strategies aimed at restoring glutathione concentration and homeostasis are effective in ameliorating or modifying the natural history of these states is unknown.
M, Reid, F, Jahoor
openaire +2 more sources
Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases. However, whether strategies aimed at restoring glutathione concentration and homeostasis are effective in ameliorating or modifying the natural history of these states is unknown.
M, Reid, F, Jahoor
openaire +2 more sources