Results 251 to 260 of about 554,348 (295)
Some of the next articles are maybe not open access.
Glutathione and glutathione analogues; Therapeutic potentials
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013Glutathione (GSH) and related enzymes are critical to cell protection from toxins, both endogenous and environmental, including a number of anti-cancer cytotoxic agents.Enhancing GSH and associated enzymes represents a longtime and persistent aim in the search for cytoprotective strategies against cancer, neurologic degeneration, pulmonary and ...
Jian Hui, Wu, Gerald, Batist
openaire +2 more sources
Glutathione Peroxidase and Glutathione Reductase Activities toward Glutathione-Derived Antioxidants
Biochemical and Biophysical Research Communications, 1994A new class of glutathione derivatives with antioxidant properties has been prepared by transformation of the NH2 group into a pyrrole ring with various substitutions at the 2 and 5 positions. Due to steric hindrance and/or hydrophobicity of the 2-5-disubstituted pyrrole ring, the reduced glutathione derivatives are poor substrates of the glutathione ...
J M, Gaullier +5 more
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Glutathione (GSH) is synthesized in the cytoplasm but there is a requirement for glutathione not only in the cytoplasm, but in the other organelles and the extracellular milieu. GSH is also imported into the cytoplasm. The transports of glutathione across these different membranes in different systems have been biochemically demonstrated.
Anand K, Bachhawat +3 more
openaire +2 more sources
Glutathione (GSH) is synthesized in the cytoplasm but there is a requirement for glutathione not only in the cytoplasm, but in the other organelles and the extracellular milieu. GSH is also imported into the cytoplasm. The transports of glutathione across these different membranes in different systems have been biochemically demonstrated.
Anand K, Bachhawat +3 more
openaire +2 more sources
Antioxidants & Redox Signaling, 2017
Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
openaire +2 more sources
Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
openaire +2 more sources
Detoxication reactions of glutathione and glutathione transferases
Xenobiotica, 1986(1986). Detoxication reactions of glutathione and glutathione transferases. Xenobiotica: Vol. 16, No. 10-11, pp. 957-973.
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
With increasing evidence that hydroperoxides are not only toxic but rather exert essential physiological functions, also hydroperoxide removing enzymes have to be re-viewed. In mammals, the peroxidases inter alia comprise the 8 glutathione peroxidases (GPx1-GPx8) so far identified.Since GPxs have recently been reviewed under various aspects, we here ...
Brigelius Flohé R, MAIORINO, MATILDE
openaire +2 more sources
With increasing evidence that hydroperoxides are not only toxic but rather exert essential physiological functions, also hydroperoxide removing enzymes have to be re-viewed. In mammals, the peroxidases inter alia comprise the 8 glutathione peroxidases (GPx1-GPx8) so far identified.Since GPxs have recently been reviewed under various aspects, we here ...
Brigelius Flohé R, MAIORINO, MATILDE
openaire +2 more sources
[Glutathione and glutathione assays].
Acta medica (Hradec Kralove). Supplementum, 2006Glutathione, the very important intracellular antioxidant, is present in intracelullar environment in milimolar concentrations. Glutathione is a tripeptide molecule, which plays an essential role in the antioxidant system, as well as in maintenance of the intracellular redox state.
Tomás, Rousar +5 more
openaire +1 more source
Analytical Biochemistry, 1980
Abstract The total glutathione content of biological samples is conveniently determined with an enzymatic recycling assay based on glutathione reductase ( F. Tietze, 1969 , Anal. Biochem. 27 , 502–522). In the original and several subsequent descriptions of this procedure, glutathione disulfide is selectively determined by assaying samples in which
openaire +2 more sources
Abstract The total glutathione content of biological samples is conveniently determined with an enzymatic recycling assay based on glutathione reductase ( F. Tietze, 1969 , Anal. Biochem. 27 , 502–522). In the original and several subsequent descriptions of this procedure, glutathione disulfide is selectively determined by assaying samples in which
openaire +2 more sources
Glutathione and detoxification
Cancer Treatment Reviews, 1990Cisplatin is recognized as one of the most effective drugs in the treatment of a variety of solid tumors. Its therapeutic usefulness has been limited by acute and cumulative nephrotoxicity ( 13). This side-effect is dose-dependent and requires adequate protective measures.
M, Tedeschi +6 more
openaire +2 more sources
Current Opinion in Clinical Nutrition and Metabolic Care, 2001
Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases. However, whether strategies aimed at restoring glutathione concentration and homeostasis are effective in ameliorating or modifying the natural history of these states is unknown.
M, Reid, F, Jahoor
openaire +2 more sources
Altered glutathione metabolism in association with increased oxidative stress has been implicated in the pathogenesis of many diseases. However, whether strategies aimed at restoring glutathione concentration and homeostasis are effective in ameliorating or modifying the natural history of these states is unknown.
M, Reid, F, Jahoor
openaire +2 more sources