Results 51 to 60 of about 53,702 (285)

Analytical methods for determination of glutathione and glutathione disulfide in pharmaceuticals and biological fluids

Reviews in Analytical Chemistry, 2020
Glutathione is a natural tripeptide that plays a major role in different physiological processes in the human body. Determination of glutathione in different body fluids and tissues is essential for early diagnosis and follow-up of various diseases.
Hamad Amal, Elshahawy Mohamed, Negm Amr, Mansour Fotouh R.   +3 more
doaj   +1 more source

The dithiol mechanism of class I glutaredoxins promotes specificity for glutathione as a reducing agent

Redox Biology
Class I glutaredoxins reversibly reduce glutathione- and nonglutathione disulfides with the help of reduced glutathione (GSH) using either a monothiol mechanism or a dithiol mechanism.
Lukas Lang, Philipp Reinert, Cedric Diaz, Marcel Deponte   +3 more
doaj   +1 more source

Investigation of the thiol-disulfide system state of rats with encephalopathy caused by the effect of antituberculous drugs

Patologìâ, 2019
Objective. To determine in an experimental study the nature of changes in the status of the thiol-disulfide system of rats with encephalopathy, due to the influence of complex of anti-tuberculosis drugs for the treatment of chemoresistant tuberculosis ...
A. V. Levich, N. O. Skorokhodova, D. H. Zhyvytsia, Yu. V. Prosvetov   +3 more
doaj   +1 more source

Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice. [PDF]

PLoS ONE, 2012
We report here that spermatozoa of mice lacking both the sperm nucleus glutathione peroxidase 4 (snGPx4) and the epididymal glutathione peroxidase 5 (GPx5) activities display sperm nucleus structural abnormalities including delayed and defective nuclear ...
Anaïs Noblanc, Manon Peltier, Christelle Damon-Soubeyrand, Nicolas Kerchkove, Eléonore Chabory, Patrick Vernet, Fabrice Saez, Rémi Cadet, Laurent Janny, Hanae Pons-Rejraji, Marcus Conrad, Joël R Drevet, Ayhan Kocer   +12 more
doaj   +1 more source

Immunoproteomic to identify antigens in the intestinal mucosa of Crohn's disease patients. [PDF]

PLoS ONE, 2013
Incidences of Crohn disease (CD) have increased significantly in the last decade. Immunoproteomics are a promising method to identify biomarkers of different diseases. In the present study, we used immunoproteomics to study proteins of intestinal mucosal
Zheng Zhou, Haiyan Liu, Guosheng Gu, Gefei Wang, Wenyong Wu, Changle Zhang, Jianan Ren   +6 more
doaj   +1 more source

Glutathione-Dependent Pathways of Refolding of RNase T₁ by Oxidation and Disulfide Isomerization:  Catalysis by Protein Disulfide Isomerase^†,‡

, 2016
Protein folding, associated with oxidation and isomerization of disulfide bonds, was studied using reduced and denatured RNase T1 (rd-RNase T1) and mixed disulfide between glutathione and reduced RNase T1 (GS-RNase T1) as starting materials.
Robert B. Freedman (510853), Gennaro Marino (1505608), Piero Pucci (21884), Margherita Ruoppolo (2388445)   +3 more
core   +1 more source

Assessment of thiol-disulfide and glutathione homeostasis after levothyroxine replacement in individuals with autoimmune or nonautoimmune hypothyroidism [PDF]

Archives of Endocrinology and Metabolism
Objective Thyroid hormones are known to affect the biosynthesis and degradation of antioxidant compounds, suggesting a possible link between hypothyroidism and oxidative stress.
Almila Senat, Osman Erinc, Soner Yesilyurt, Gamze Gok, Ozcan Erel   +4 more
doaj   +1 more source

Bioorthogonal Photoactivation of 2‐Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars

Advanced Materials, EarlyView.
Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno, Andrea Escudero, Oscar Ferreira Silvestre, José Manuel Terrés, Mónica Gorbe, Eva Garrido, Carlos Renero‐Lecuna, Judith Langer, María Alfonso, Javier Ibañez, Félix Sancenón, Roberto Cao‐Milán, Luis M. Liz‐Marzán, Alba García‐Fernández, Andy Hernández‐Montoto, Ramón Martínez‐Máñez   +15 more
wiley   +1 more source

Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment

Materials Research Express, 2023
Vitamin E Poly(ethylene glycol) monoplatinum ester (TPGS) nanoparticles have attracted much attention in recent years for overcome multidrug resistance. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked polymer (FA-SS-TPGS) was ...
Zhuoran Li, Huikang Yang, Fan Xu, Xuwen Zeng, Haowei Huang, Xinqing Jiang   +5 more
doaj   +1 more source

Pharmacology of a mimetic of glutathione disulfide, NOV-002 [PDF]

Biomedicine & Pharmacotherapy, 2009
NOV-002 is a novel therapeutic agent in development for oncology indications used in combination with chemotherapy. Clinical trials in Russia and the USA have demonstrated clinical activity and the present focus is on non-small cell lung cancer (NSCLC) patients.
Danyelle M, Townsend, Kenneth D, Tew
openaire   +2 more sources