Results 31 to 40 of about 53,702 (285)

Endoplasmic reticulum H₂O₂ : Ero1-driven generation and GPx-mediated detoxification [PDF]

, 2014
Endoplasmic reticulum (ER) oxidoreductin 1 alpha (Ero1alpha) is an ER-resident oxidase, which utilizes molecular oxygen (O2) as terminal electron acceptor to produce disulfide bonds and hydrogen peroxide (H2O2).
Ramming, Thomas
core   +1 more source

Glutathione Peroxide and Glutathione to Disulfide Glutathione Ratio in Presbycusis: a Case-control Study

Medical Archives, 2022
Background: Presbycusis is a gradual hearing loss caused by the ageing process. This is a chronic condition that affects the elderly population, and sensorineural progressive bilateral symmetry occurs with predominantly high-frequency hearing loss. The ability to discriminate speech decreases; hence, most of the affected patients have conversation ...
Hasansulama, Wijana, Madiadipoera, Teti S, Sunarjati,, Garna, Herry   +3 more
openaire   +2 more sources

Intracellular glutathione pools are heterogeneously concentrated [PDF]

, 2013
Glutathione is present in millimolar concentrations in the cell, but its relative distribution among cellular compartments remains elusive. We have chosen the endoplasmic reticulum (ER) as an example organelle to study compartment-specific glutathione ...
Christine Tachibana, Jakob Rahr Winther, Rahr Winther, Jakob, Winther, Jakob R., Appenzeller-Herzog, Christian, Davide Montero, Tachibana, Christine, Christian Appenzeller-Herzog, Montero, Davide   +8 more
core   +1 more source

An Orally Bioavailable (Mice) Prodrug of Glutathione

Antioxidants, 2021
L-Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH), was found to be orally bioavailable in mice, and protected mice against a toxic dose of acetaminophen.
Daune L. Crankshaw, Jacquie E. Briggs, Robert Vince, Herbert T. Nagasawa   +3 more
doaj   +1 more source

Glutathione treatment protects the rat liver against injury after warm ischemia and Kupffer cell activation [PDF]

, 2002
Background/Aim: The generation of reactive oxygen species by activated Kupffer cells (KC) may contribute to reperfusion injury of the liver during liver transplantation or resection.
Schauer, R., Rolf Schauer, Andreas Baron, Christian Steib, Ebensberger, S., Stefan Ebensberger, Manfred Bilzer, Steib, C., Alexander L. Gerbes, Baron, A., Bilzer, M., Gerbes, Alexander L.   +11 more
core   +1 more source

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

Cell Reports, 2017
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively ...
Justin R. Prigge, Lucia Coppo, Sebastin S. Martin, Fernando Ogata, Colin G. Miller, Michael D. Bruschwein, David J. Orlicky, Colin T. Shearn, Jean A. Kundert, Julia Lytchier, Alix E. Herr, Åse Mattsson, Matthew P. Taylor, Tomas N. Gustafsson, Elias S.J. Arnér, Arne Holmgren, Edward E. Schmidt   +16 more
doaj   +1 more source

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress [PDF]

, 2016
The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and ...
Sanguinetti, Guido, Holyoake, L.V., Rowe, Michelle L, Holyoake, Louise V, Howard, Mark J., Sanguinetti, G., Howard, Mark J, Rowe, M.L., Poole, Robert K, Poole, R.K., Hunt, Stuart, Cook, Gregory M, Hunt, S., Shepherd, M., Rowe, Michelle L., Shepherd, Mark, Howard, M.J., Cook, G.M.   +17 more
core   +1 more source

The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more [PDF]

, 2012
Significance: The oxidative process of disulfide-bond formation is essential for the folding of most secretory and membrane proteins in the endoplasmic reticulum (ER).
Ramming, Thomas, Appenzeller-Herzog, Christian   +1 more
core   +1 more source

Differential activity of rice protein disulfide isomerase family members for disulfide bond formation and reduction

FEBS Open Bio, 2014
Protein disulfide isomerases (PDIs), a family of thiol-disulfide oxidoreductases that are ubiquitous in all eukaryotes, are the principal catalysts for disulfide bond formation. Here, we investigated three rice (Oryza sativa) PDI family members (PDIL1;1,
Yayoi Onda, Yohei Kobori
doaj   +1 more source

Dithiophosphate-Induced Redox Conversions of Reduced and Oxidized Glutathione

Molecules, 2021
Phosphorus species are potent modulators of physicochemical and bioactive properties of peptide compounds. O,O-diorganyl dithiophoshoric acids (DTP) form bioactive salts with nitrogen-containing biomolecules; however, their potential as a peptide ...
Rezeda A. Ishkaeva, Ilyas S. Nizamov, Dmitriy S. Blokhin, Elizaveta A. Urakova, Vladimir V. Klochkov, Ilnar D. Nizamov, Bulat I. Gareev, Diana V. Salakhieva, Timur I. Abdullin   +8 more
doaj   +1 more source