Results 21 to 30 of about 53,702 (285)

An Artifact-Free Assay for the GSH/GSSG Ratio Adapted for Finger-Stick Blood Microvolumes: Simple, Sensitive, and Suitable for Any Laboratory [PDF]

Antioxidants
Blood glutathione (GSH), its oxidized form glutathione disulfide (GSSG), and especially the ratio of reduced to oxidized glutathione (GSH/GSSG) are recognized as robust biomarkers of oxidative stress.
Daniela Giustarini, Graziano Colombo, Isabella Dalle-Donne, Ranieri Rossi   +3 more
doaj   +2 more sources

In Vitro and In Vivo Tumor Growth Inhibition by Glutathione Disulfide Liposomes [PDF]

Cancer Growth and Metastasis, 2017
Rakesh Dachineni, Xiangming Guan
exaly   +2 more sources

The Status of Antioxidants and Oxidative Damage in Patients with COVID-19

Ahi Evran Medical Journal, 2023
Purpose: COVID-19 is a viral disease that has recently caused a pandemic and significantly affects human health. In this study, superoxide dismutase, glutathione peroxidase, glutathione, total thiol, natural thiol, disulfide, oxidative DNA damage and ...
İrfan BİNİCİ, Hamit Hakan ALP, Zübeyir HUYUT, Esra GÜRBÜZ, Hülya GÜNBATAR, Şükrü AKMEŞE, Mustafa Kasım KARAHOCAGİL, Halil İbrahim AKBAY   +7 more
doaj   +1 more source

Elemental Sulfur Inhibits Yeast Growth via Producing Toxic Sulfide and Causing Disulfide Stress

Antioxidants, 2022
Elemental sulfur is a common fungicide, but its inhibition mechanism is unclear. Here, we investigated the effects of elemental sulfur on the single-celled fungus Saccharomyces cerevisiae and showed that the inhibition was due to its function as a strong
Tianqi Wang, Yuqing Yang, Menghui Liu, Honglei Liu, Huaiwei Liu, Yongzhen Xia, Luying Xun   +6 more
doaj   +1 more source

Introduction of a More Glutaredoxin-like Active Site to PDI Results in Competition between Protein Substrate and Glutathione Binding

Antioxidants, 2022
Proteins in the thioredoxin superfamily share a similar fold, contain a -CXXC- active site, and catalyze oxidoreductase reactions by dithiol-disulfide exchange mechanisms. Protein disulfide isomerase (PDI) has two -CGHC- active sites.
Mirva J. Saaranen, Heli I. Alanen, Kirsi E. H. Salo, Emmanuel Nji, Pekka Kärkkäinen, Constanze Schmotz, Lloyd W. Ruddock   +6 more
doaj   +1 more source

Environmentally friendly recycling system for epoxy resin with dynamic covalent bonding

Science and Technology of Advanced Materials, 2021
Recycling of epoxy resin and its composites is extremely difficult due to its thermoset nature. In this study, we proposed the environmentally-friendly recycling system of epoxy resin with dynamic covalent bonding in the assistance of cysteine-containing
Hsing-Ying Tsai, Takehiro Fujita, Siqian Wang, Masanobu Naito   +3 more
doaj   +1 more source

Erythrocytic Reduced/Oxidized Glutathione and Serum Thiol/Disulfide Homeostasis in Patients with Opioid Use Disorder

, 2023
Background: This study aimed to evaluate oxidative damage by measuring erythrocytic reduced/oxidized glutathione as an intracellular thiol pool and serum thiol/disulfide homeostasis as an extracellular thiol pool in patients with opioid use disorder ...
Almila Şenat, Erel, Özcan, Özcan Erel, Şahin, Esra Kabadayı, Tomris Duymaz, Senat, Almila, Duymaz, Tomris, İbrahim Söğüt, Esra Kabadayı Şahin, Söğüt, İbrahim   +9 more
core   +1 more source

Glutathione cycle in diquat neurotoxicity: Assessed by intrastriatal pre-treatment with glutathione reductase [PDF]

Acta Veterinaria, 2013
Diquat (DQ) neurotoxicity mechanisms are unknown, although, it's systemic toxicity is mediated by free radical reactions. The role of glutathione cycle was assessed by glutathione reductase (GR) applied in the pre-treatment of DQ poisoning.
Đurđević Dragan, Đukić Mirjana, Ninković Milica, Stevanović Ivana, Jovanović Marina, Vasić Una   +5 more
doaj   +1 more source

The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis

Redox Biology, 2023
Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state.
Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Luís Gales, Armindo Salvador, Tânia Francisco, Jorge E. Azevedo   +6 more
doaj   +1 more source

NOV-002, a mimetic of glutathione disulfide [PDF]

Expert Opinion on Investigational Drugs, 2008
Oxidative signaling to modulate redox-sensitive cell functions is a heretofore unexploited approach to developing new drugs for poorly treated oncology indications, where current therapies are often only palliative and accompanied by severe toxicities.Clinical and non-clinical findings with NOV-002 (a mimetic of glutathione disulfide that represents ...
Danyelle M, Townsend, Christopher J, Pazoles, Kenneth D, Tew   +2 more
openaire   +2 more sources