Results 71 to 80 of about 77,313 (353)

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress [PDF]

, 2016
The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and ...
Cook, Gregory M, Holyoake, Louise V, Howard, Mark J., Hunt, Stuart, Poole, Robert K, Rowe, Michelle L., Sanguinetti, Guido, Shepherd, Mark   +7 more
core   +3 more sources

Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes

Advanced Functional Materials, EarlyView.
Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen, Andreas B. Pedersen, Mireia Casanovas Montasell, Søren Moesgaard, Anja Bille Bohn, Alexander N. Zelikin   +5 more
wiley   +1 more source

Pharmacology of a mimetic of glutathione disulfide, NOV-002 [PDF]

Biomedicine & Pharmacotherapy, 2009
NOV-002 is a novel therapeutic agent in development for oncology indications used in combination with chemotherapy. Clinical trials in Russia and the USA have demonstrated clinical activity and the present focus is on non-small cell lung cancer (NSCLC) patients.
Danyelle M. Townsend, Kenneth D. Tew
openaire   +3 more sources

The cysteine-rich protein thimet oligopeptidase as a model of the structural requirements for S-glutathiolation and oxidative oligomerization. [PDF]

PLoS ONE, 2012
Thimet oligopeptidase (EP24.15) is a cysteine-rich metallopeptidase containing fifteen Cys residues and no intra-protein disulfide bonds. Previous work on this enzyme revealed that the oxidative oligomerization of EP24.15 is triggered by S ...
Alberto Malvezzi, Patrícia M Higa, Antonia T-do Amaral, Gustavo M Silva, Fabio C Gozzo, Emer S Ferro, Leandro M Castro, Leandro de Rezende, Gisele Monteiro, Marilene Demasi   +9 more
doaj   +1 more source

Glutathione and Glutaredoxin in Redox Regulation and Cell Signaling of the Lens

Antioxidants, 2022
The ocular lens has a very high content of the antioxidant glutathione (GSH) and the enzymes that can recycle its oxidized form, glutathione disulfide (GSSG), for further use.
Marjorie F. Lou
doaj   +1 more source

Expression of active human sialyltransferase ST6GalNAcI in Escherichia coli [PDF]

, 2009
Georgios Skretas, Sean Carroll, and George Georgiou are with the Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA -- George Georgiou is with the Department of Biomedical Engineering, University of Texas at Austin ...
Carroll, Sean, DeFrees, Shawn, Georgiou, George, Johnson, Karl F., Schwartz, Marc F., Skretas, Georgios   +5 more
core   +3 more sources

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

The mammalian peroxisomal membrane is permeable to both GSH and GSSG – Implications for intraperoxisomal redox homeostasis

Redox Biology, 2023
Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state.
Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Luís Gales, Armindo Salvador, Tânia Francisco, Jorge E. Azevedo   +6 more
doaj  

Vapor Phase Growth and Grain Boundary Structure of Molybdenum Disulfide Atomic Layers [PDF]

, 2013
Single layered molybdenum disulfide with a direct bandgap is a promising two-dimensional material that goes beyond graphene for next generation nanoelectronics. Here, we report the controlled vapor phase synthesis of molybdenum disulfide atomic layers and elucidate a fundamental mechanism for the nucleation, growth, and grain boundary formation in its ...
arxiv   +1 more source

Precise Molecular Structures of Cysteine, Cystine, Hydrogen-Bonded Dicysteine, Cysteine Dipeptide, Glutathione and Acetyl Cysteine Based on Additivity of Atomic Radii [PDF]

, 2011
Structures of molecules are usually represented by arbitrary line drawings, ball and stick or space filling models. In recent years, the author found that using the appropriate radii of atoms and ions, bond lengths in inorganic, organic and biomolecules ...
Raji Heyrovska
core   +1 more source