Results 1 to 10 of about 508,182 (337)

Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells

Frontiers in Oncology, 2022
BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Yiming Ma, Jianhui Ma, Lan Yang, Qingzhi Song, Hongying Wang, Guoqing Lv   +8 more
doaj   +2 more sources

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer’s disease [PDF]

Neural Regeneration Research
Alzheimer’s disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer’s disease has not yet been found.
Yanxin Shen, Guimei Zhang, Chunxiao Wei, Panpan Zhao, Yongchun Wang, Mingxi Li, Li Sun   +6 more
doaj   +2 more sources

Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk. [PDF]

PLoS ONE, 2013
Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear.
Catherine Méplan, Lars Ove Dragsted, Gitte Ravn-Haren, Anne Tjønneland, Ulla Vogel, John Hesketh   +5 more
doaj   +2 more sources

Diabetic Retinopathy and Regulation of Mitochondrial Glutathione–Glutathione Peroxidase Axis in Hyperhomocysteinemia [PDF]

Antioxidants
Diabetic patients have elevated homocysteine levels, and hyperhomocysteinemia is shown to exacerbate mitochondrial damage, which plays a central role in diabetic retinopathy. Glutathione peroxidases (GPx) catalyze hydrogen peroxide (H2O2) reduction using
Pooja Malaviya, Renu A. Kowluru
doaj   +2 more sources

Glutathione peroxidase: A selenoenzyme [PDF]

FEBS Letters, 1973
Flohe, L., Günzler, W.A., Schock, H.H.
openaire   +3 more sources

Research progress of glutathione peroxidase family (GPX) in redoxidation

Frontiers in Pharmacology, 2023
Maintaining the balance of a cell’s redox function is key to determining cell fate. In the critical redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent family of proteins with a multifaceted function that affects almost ...
Jun Pei, Xingyu Pan, Guanghui Wei, Yi Hua   +3 more
semanticscholar   +1 more source

Glutathione peroxidase 4 regulated neutrophil ferroptosis induces systemic autoimmunity

Nature Immunology, 2021
The linkage between neutrophil death and the development of autoimmunity has not been thoroughly explored. Here, we show that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus (SLE) undergo ferroptosis ...
Pengchong Li, M. Jiang, Ketian Li, Hao Li, Yang-zhong Zhou, Xin-yue Xiao, Yue Xu, S. Krishfield, P. Lipsky, G. Tsokos, Xuan Zhang   +10 more
semanticscholar   +1 more source

Glutathione Peroxidase 2 [PDF]

Definitions, 2020
openaire   +2 more sources

The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

Biomedicines, 2022
The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a ...
Kamari Weaver, R. Skouta
semanticscholar   +1 more source

Long-term results of the enzyme glutation system activity in experimental ovarian cancer

Journal of Education, Health and Sport, 2022
The article presents the experimental results of the investigation the glutathione system activity (glutathione peroxidase and glutathione reductase) in rats simulated ovarian ascites tumor.
L. Yershova, R. Yeromenko, I. Savytskyi, T. Alexandryna, L. Sarakhan   +4 more
doaj   +1 more source