Research progress of glutathione peroxidase family (GPX) in redoxidation. [PDF]
Front Pharmacol, 2023 Maintaining the balance of a cell’s redox function is key to determining cell fate. In the critical redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent family of proteins with a multifaceted function that affects almost ...
Pei J, Pan X, Wei G, Hua Y.
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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer’s disease [PDF]
Neural Regeneration ResearchAlzheimer’s disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer’s disease has not yet been found.
Yanxin Shen +6 more
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Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk. [PDF]
PLoS ONE, 2013 Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear.
Catherine Méplan +5 more
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The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis—A systematic review and meta‐analysis [PDF]
Clinical and Experimental Dental ResearchObjective The present systematic review explored the involvement of enzymatic and nonenzymatic antioxidants in periodontitis, drawing from established literature. Materials and Methods The research approach encompassed an extensive electronic search from
Khadijah Mohideen +5 more
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Diabetic Retinopathy and Regulation of Mitochondrial Glutathione–Glutathione Peroxidase Axis in Hyperhomocysteinemia [PDF]
AntioxidantsDiabetic patients have elevated homocysteine levels, and hyperhomocysteinemia is shown to exacerbate mitochondrial damage, which plays a central role in diabetic retinopathy. Glutathione peroxidases (GPx) catalyze hydrogen peroxide (H2O2) reduction using
Pooja Malaviya, Renu A. Kowluru
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Glutathione peroxidase: A selenoenzyme [PDF]
FEBS Letters, 1973 H.H. Schock +2 more
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Glutathione peroxidase 4 regulated neutrophil ferroptosis induces systemic autoimmunity
Nature Immunology, 2021 The linkage between neutrophil death and the development of autoimmunity has not been thoroughly explored. Here, we show that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus (SLE) undergo ferroptosis ...
Pengchong Li +10 more
semanticscholar +1 more source
Biomedicines, 2022 The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a ...
Kamari Weaver, R. Skouta
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Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer
Cancers, 2022 Simple Summary Glutathione peroxidase 1 (GPX1), as one of the most important antioxidant enzymes, maintains cellular redox balance by regulating reactive oxygen species levels.
Yangjing Zhao +3 more
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Long-term results of the enzyme glutation system activity in experimental ovarian cancer
Journal of Education, Health and Sport, 2022 The article presents the experimental results of the investigation the glutathione system activity (glutathione peroxidase and glutathione reductase) in rats simulated ovarian ascites tumor.
L. Yershova +4 more
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