Results 41 to 50 of about 167,749 (264)
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
Oxidant-Antioxidant disturbance in men classified as obese according to the preliminary WHO guidelines for Asians [PDF]
Journal of Stress Physiology & Biochemistry, 2012 Background: Though there are experimental and clinical evidences regarding oxidant-antioxidant disturbance in obese subjects, clinical data supporting the same in Indian male subjects is lacking.
Selvakumar C +3 more
doaj
Otoprotection Mechanisms Against Oxidative Stress Caused by Cisplatin
International Archives of Otorhinolaryngology, 2020 Introduction Cisplatin damages the auditory system and is related to the generation of free radicals. Glutathione peroxidase is an endogenous free radicals remover.
Maiara Santos Gonçalves +4 more
doaj +1 more source
Advanced Science, EarlyView.Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang +6 more
wiley +1 more source
Response of antioxidant system of tomato to water deficit stress and its interaction with ascorbic acid [PDF]
Zīst/shināsī-i Giyāhī-i Īrān, 2014 Environmental stresses including water deficit stress may produce oxidants such as reactive oxygen species that damage the membrane structure in plants.
Fatemeh Daneshmand
doaj
AGE-RELATED CHARACTERISTICS OF GLUTATHIONE-DEPENDENT ENZYMES FUNCTIONING IN RATS UNDER CONDITIONS OF TOXIC INJURY BY ACETAMINOPHEN [PDF]
Biotechnologia ActaAim. The study is dedicated to evaluating the enzymatic activities of the glutathione system in liver cells of rats from different age groups under conditions of toxic injury caused by acetaminophen.
М.S. URSATYI +2 more
doaj +1 more source
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
Antioxidant status in women with uterine leiomyoma: relation with sex hormones
Anais da Academia Brasileira de Ciências, 2015 Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients ...
SNEŽANA PEJIĆ +5 more
doaj +1 more source
Catalase and glutathione peroxidase mimics [PDF]
Biochemical Pharmacology, 2009 Overproduction of the reactive oxygen species (ROS) superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) are increasingly implicated in human disease and aging. ROS are also being explored as important modulating agents in a number of cell signaling pathways.
openaire +2 more sources
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source