Results 111 to 120 of about 122,606 (315)
Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT
Advanced Science, EarlyView.Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li +8 more
wiley +1 more source
Age-related oxidative stress in patients with pyelonephritis
Український Журнал Нефрології та Діалізу, 2018 The objective of the present study was to compare age-related oxidative stress in pediatric and adult patients with pyelonephritis. Methods. This research is focused on the age features of change of oxidant-antioxidant parameters and intensity of ...
L.V. Korol +3 more
doaj +1 more source
Advanced Science, EarlyView.The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang +12 more
wiley +1 more source
Ecotoxicology and Environmental Safety, 2022 Lysine crotonylation is a protein post-translational modification that has been newly discovered in recent years. There are few studies on the lysine crotonylation of proteins in plants, and their functions in response to cold stress are still unclear ...
Xiaohan Yang +13 more
doaj
Correlation between frost tolerance and antioxidant activities in cereals [PDF]
, 2002 Frost-tolerant and frost-sensitive cereal species were hardened at low, nonfreezing temperature. Changes in the activity of antioxidant enzymes (catalase, ascorbate peroxidase, guaiacol peroxidase, glutathione-S-transferase and glutathione reductase) in ...
Janda, Tibor
core
Biomarkers of selenium status in dogs [PDF]
, 2016 Background: Inadequate dietary selenium (Se) intake in humans and animals can lead to long term health problems, such as cancer. In view of the owner's desire for healthy longevity of companion animals, the impact of dietary Se provision on long term ...
Du Laing, Gijs +5 more
core +2 more sources
Advanced Science, EarlyView.Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu +13 more
wiley +1 more source
Lipid metabolism in pancreatic cancer: emerging roles and potential targets
Cancer Communications, Volume 42, Issue 12, Page 1234-1256, December 2022., 2022 Abstract Pancreatic cancer is one of the most serious health issues in developed and developing countries, with a 5‐year overall survival rate currently <9%. Patients typically present with advanced disease due to vague symptoms or lack of screening for early cancer detection.
Xinpeng Yin +6 more
wiley +1 more source
Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2019 The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease.
Mikola Shustval +4 more
doaj +1 more source
Nimesulide limits kainate-induced oxidative damage in the rat hippocampus [PDF]
European Journal of Pharmacology 390(3): 295-298 (2000), 2007 Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus.
arxiv