Results 101 to 110 of about 278,744 (306)

Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape [PDF]

, 2013
Peer reviewedPublisher ...
Alarco AM, Alessandra da Silva Dantas, Brian A. Morgan, Christopher G. McKenzie, Deborah A. Smith, Donna M. MacCallum, Elizabeth A. Veal, Janet Quinn, Lars-Peter Erwig, Miranda J. Patterson, Sam Sherston, Vazquez-Torres A, Wysong DR   +12 more
core   +1 more source

Catalase and glutathione peroxidase mimics [PDF]

Biochemical Pharmacology, 2009
Overproduction of the reactive oxygen species (ROS) superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) are increasingly implicated in human disease and aging. ROS are also being explored as important modulating agents in a number of cell signaling pathways.
openaire   +2 more sources

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

Horseradish and soybean peroxidases: comparable tools for alternative niches? [PDF]

, 2006
Horseradish and soybean peroxidases (HRP and SBP, respectively) are useful biotechnological tools. HRP is often termed the classical plant heme peroxidase and although it has been studied for decades, our understanding has deepened since its cloning and ...
Alonso Lomillo, Alpeeva, Azevedo, Azevedo, Azevedo, Barry J. Ryan, Bruns, Bódalo, Campanella, Castilho, Castillo, Chen, Cho, Ciarán Ó’Fágáin, Colas, Dachs, Dai, Dai, dos Santos, Dotsikas, Dunford, Duroux, Ferapontova, Ferapontova, Ferapontova, Folkes, Gajhede, Gazaryan, Gazaryan, Gijzen, Gray, Gustafsson, Henriksen, Hoffmann, Howes, Howes, Howes, Hoyle, Hushpulian, Ignatenko, Jung, Kamal, Kamiya, Katz, Kazlauskas, Kenausis, Kim, Kim, Klibanov, Knutson, Konash, Kreiner, Lee, Lei, Li, Li, Lin, Lin, Lindgren, Liu, Luong, Mendive, Michizoe, Morawski, Morawski, Morgan, Morimoto, Mukai, Nagano, Neil Carolan, Newmyer, Newmyer, Nicell, Ozaki, Patel, Paul, Penalva, Poljaková, Rahman, Rauf, Rodriguez-Lopez, Rossiter, Sakharov, Schmitz, Schuvailo, Shipovskov, Smith, Smith, Song, Sun, Tafazoli, Tanaka, Teilum, Tupper, Tønning, van de Velde, van de Velde, Varnado, Veitch, Veitch, Veitch, Veitch, Verpoorte, Vreeke, Wandersman, Wang, Wang, Wanger, Welinder, Welinder, Welinder, Won, Woodard, Wu, Wuhrer, Yan, Yuan, Zhang, Zhang, Zhu   +119 more
core   +2 more sources

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Identification of Mammalian Mediator Subunits with Similarities to Yeast Mediator Subunits Srb5, Srb6, Med11, and Rox3 [PDF]

, 2003
The Mediator is a multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators. We recently identified a mammalian homologue of yeast Mediator subunit Med8 and partially purified a Med8-containing ...
Banks, Charles A. S., Brower, Christopher S., Cai, Yong, Conaway, Joan Weliky, Conaway, Ronald C., Jin, Jingji, Kong, Stephanie E., Lane, William S., Parmely, Tari J., Sato, Shigeo, Sorokina, Irina, Tomomori-Sato, Chieri   +11 more
core   +2 more sources

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

Advanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
wiley   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Antioxidant Effects of Some Drugs on Ethanol-induced Ulcers

Molecules, 2009
The aim of this work was to investigate the antioxidant potential of some commonly used drugs (bromocriptine, haloperidol and azithromycin) on alcohol-induced ulcers in the rat.
Svetlana Trivic, Julijana Rasic, Biljana Kaurinovic, Snezana Janicijevic-Hudomal, Mira Popovic   +4 more
doaj   +1 more source