Results 111 to 120 of about 167,749 (264)

Enhanced protocol for measuring glutathione peroxidase activity using a new glutathione peroxidase-Tiron assay. [PDF]

Biol Methods Protoc
Hadwan MH, Mohammed AA, Najavand S, Altaee R, Hadwan AM.   +4 more
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Redox protection by bacterial glutathione peroxidase drives virulence in <i>Pseudomonas aeruginosa</i>. [PDF]

Redox Rep
da Silva Cordeiro J, Correia TML, Muniz IPR, da Silva RP, Dos Santos TC, Rocha LS, Yatsuda R, Borges JO, Souza Peixoto A, de Magalhães ACM, da Silva RAA, Meotti FC, Queiroz RF.   +12 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis. [PDF]

FASEB J
Fliflet AM, Spradlin RA, Tan Y, Nishitha Vijayan A, Choi SJ, Kao WC, Aksamitiene E, Nelappana M, Ding S, Huang KY, Joshi A, Kambar N, Bludgen T, Meehan M, Boss JL, Knipp M, Fan H, Leal C, Sunde RA, Dobrucki LW, Boppart SA, Kong HJ, Sweedler JV, Boppart MD.   +23 more
europepmc   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Erythrocyte glutathione peroxidase (GSH-Px) polymorphism in Finnsheep

Genetics Selection Evolution, 1982
Sandholm M, Oeterberg S, Sankari S, Atroshi F   +3 more
doaj   +1 more source

Glutathione peroxidase 2 expression in human tumors: a tissue microarray study on 18,555 tumors. [PDF]

Front Oncol
Chirico V, Jahn N, Büyücek S, Schraps N, Lennartz M, Möller K, Bady E, Hornsteiner L, Plage H, Hube-Magg C, Kluth M, Jacobsen F, Viehweger F, Dum D, Hinsch A, Fraune C, Bernreuther C, Lebok P, Sauter G, Clauditz TS, Krech T, Marx AH, Simon R, Burandt E, Gorbokon N, Minner S, Steurer S.   +26 more
europepmc   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

Ubiquitin-Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4. [PDF]

Cancer Med
Huang M, Fang M, Wang Y, Liu S, Li F.
europepmc   +1 more source