Results 81 to 90 of about 371,704 (300)

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

IMPACT OF DIETARY ADDITION OF NETTLE PLANT AS A NATURAL ANTIOXIDANT ON THE PHYSIOLOGICAL PERFORMANCE OF BROILER [PDF]

Mesopotamia Journal of Agriculture
This study was conducted to investigate the nettle plant's physiological effects on the broilers' antioxidant status. At one day of age, 240 chicks (Ross 308) were randomly distributed in three groups (80 birds/group, weighing 40.6±0.3 g each ...
Ghadeer A. Rahawi, Wael Younis, Abdullah Abdul-Majeed   +2 more
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

24-Epibrassinolide Mediated Changes in Photosynthetic pigments and Antioxidative Defence System of Radish Seedlings under Cadmium and Mercury Stress [PDF]

Journal of Stress Physiology & Biochemistry, 2014
The present work was conducted to study the effects of 24-EBL on photosynthetic pigments (total chlorophyll, chl a, chl b, carotenoid, anthocyanin and flavonoid content) and activities of antioxidative enzymes (guaiacol peroxidase, catalase, superoxide ...
Dhriti Kapoor, Amandeep Rattan, Vandana Gautam, Nitika Kapoor, Renu Bhardwaj   +4 more
doaj  

Efeitos da exposição aguda ao selênio e ao cobre sobre as defesas antioxidantes de mexilhões marinhos Perna perna [PDF]

, 2010
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Embora muitos metais, como o cobre, sejam essenciais para os organismos, o seu uso industrial e na agricultura tem levado a um aumento de sua concentração na
Silva, Marcella Uliano da
core  

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Age-related oxidative stress in patients with pyelonephritis

Український Журнал Нефрології та Діалізу, 2018
The objective of the present study was to compare age-related oxidative stress in pediatric and adult patients with pyelonephritis. Methods.  This research is focused on the age features of change of oxidant-antioxidant parameters and intensity of ...
L.V. Korol, N.M. Stepanova, O.V. Lavrenchuk, L.Ya. Migal   +3 more
doaj   +1 more source

Glutathione peroxidase: A selenoenzyme [PDF]

FEBS Letters, 1973
Flohe, L., Günzler, W.A., Schock, H.H.
openaire   +2 more sources