Results 221 to 230 of about 487,455 (339)

Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core

Asian Journal of Organic Chemistry, EarlyView.
An efficient method to develop novel dihydropyrido[3,2‐e][1,3]selenazines iminium salts. A comparative study of the key reagent selenourea towards thiourea and urea was carried out to assess the contribution of chalcogen to the pathway. DFT (density functional theory) calculations have predicted the optimized minimum energy structure for the hybrid ...
Reinier Lemos, Mauro De Nisco, Yoana Pérez‐Badell, Gabriella Pinto, Marco Morelli, Margarita Suárez, Silvana Pedatella   +6 more
wiley   +1 more source

Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase

Angewandte Chemie, EarlyView.
Thiol reductants activate dichalcogenide probes by a cascade of partly reversible steps. Careful dichalcogenide engineering can tune the rates of these steps separately, to aim at probes that are kinetically selective for specific oxidoreductases in live cells.
Lukas Zeisel, Lucas Dessen Weissenhorn, Karoline C. Scholzen, Andrea Madabeni, Laura Orian, Elias S. J. Arnér, Oliver Thorn‐Seshold   +6 more
wiley   +2 more sources

Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer. [PDF]

Cancer Metab
Devericks EN, Brosnan BH, Ho AN, Glenny EM, Malian HM, Teegarden D, Wendt MK, Coleman MF, Hursting SD.   +8 more
europepmc   +1 more source

Induction of glutathione peroxidase by linoleic acid hydroperoxide in Hansenula mrakii.

, 1990
Yoshiharu Inoue, Takayuki Ichiryu, Koji Yoshikawa, Linh-Thuoc Tran, Kousaku Murata, Akira Kimura   +5 more
openalex   +2 more sources

Glutathione peroxidase activity is neuroprotective in models of Huntington's disease

Nature Genetics, 2013
R. Mason, M. Casu, Nicola J. Butler, C. Breda, S. Campesan, J. Clapp, E. W. Green, Devyani Dhulkhed, C. Kyriacou, F. Giorgini   +9 more
semanticscholar   +1 more source

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4‐regulated ferroptosis

Animal Models and Experimental Medicine, EarlyView.
BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen, Rui‐Rui Gao, Yan‐Yan Chen, Yi‐Jie Wang, Xin‐Tong Wang, Hai‐Xin Liu   +5 more
wiley   +1 more source

The Iron–Sulfur Cluster of Bacterioferritin‐Associated Ferredoxin (Bfd): a “Biological Fuse” that Prevents Oxidative Damage to Cells?

Angewandte Chemie, EarlyView.
When cellular iron is low, bacterioferritin (Bfr) releases its stored iron through a reductive process dependent on the [2Fe–2S] ferredoxin Bfd. Why accessing stored iron should depend on an iron‐requiring protein when iron is scarce is unclear. Here, we show that the Bfd [2Fe–2S] cluster is sensitive to oxidative stress, suggesting that it may act as ...
Justin M. Bradley, Aiden M. Carter, Zinnia Bugg, Simon C. Andrews, Nick E. Le Brun   +4 more
wiley   +2 more sources

[Retracted] Glutathione peroxidase 2 overexpression promotes malignant progression and cisplatin resistance of KRAS‑mutated lung cancer cells. [PDF]

Oncol Rep
Wang M, Chen X, Fu G, Ge M.
europepmc   +1 more source

Spontaneously Hypertensive Rat (SHR) Myocardium Glutathione Peroxidase and Membrane-lipid Peroxidation

, 1990
Mikinori Torii, Hiroyuki Ito, Tsuneyuki Suzuki   +2 more
openalex   +2 more sources

Glutathione in plants: biosynthesis and physiological role in environmental stress tolerance

Physiology and Molecular Biology of Plants, 2017
M. Hasanuzzaman, K. Nahar, T. I. Anee, M. Fujita   +3 more
semanticscholar   +1 more source