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Glutathione Peroxidase in Health and Diseases

Glutathione System and Oxidative Stress in Health and Disease, 2020
The aim of this study is to give information to readers about the importance of glutathione peroxidase. The physiopathology of most diseases is not fully elucidated currently; however, in many epidemiological studies, there are limited studies indicating
E. Sarıkaya, S. Doğan
semanticscholar   +1 more source

Metabolism of hydroperoxy-phospholipids in human hepatoma HepG2 cells

Journal of Lipid Research, 1996
Two enzymatic mechanisms have been proposed for the metabolism of hydroperoxy-phospholipids: i) the combined action of phospholipase A2 and glutathione peroxidase, and/or ii) direct enzymatic reduction.
Y Bao, G Williamson
doaj   +1 more source

Effect of ochratoxin A and buthionine sulfoximine on proteome and ascorbate-glutathione cycle enzymes in Arabidopsis thaliana

Biologia Plantarum, 2015
In this study, proteome and activities of glutathione (GSH)-related enzymes were investigated in detached leaves of Arabidopsis thaliana treated with ochratoxin A (OTA) alone or supplemented with buthionine sulfoximine (BSO, a specific inhibitor of the ...
J. R. Hao, Y. Wang, W. W. Zhao, W. T. Xu, Y. B. Luo, Z. J. Yang, W. H. Wu, Z. H. Liang, K. L. Huang   +8 more
doaj   +1 more source

Prognostic significance of glutathione peroxidase 2 in gastric carcinoma

Tumor Biology, 2017
Increasing evidence suggests that the glutathione peroxidase 2 may actually play important roles in tumorigenesis and progression in various human cancers such as colorectal carcinomas and lung adenocarcinomas. However, the role of glutathione peroxidase
Dongzhe Liu, Liang Sun, Jinxue Tong, Xiuhui Chen, Hui Li, Qifan Zhang   +5 more
doaj   +1 more source

Lysine decrotonylation of glutathione peroxidase at lysine 220 site increases glutathione peroxidase activity to resist cold stress in chrysanthemum

Ecotoxicology and Environmental Safety, 2022
Lysine crotonylation is a protein post-translational modification that has been newly discovered in recent years. There are few studies on the lysine crotonylation of proteins in plants, and their functions in response to cold stress are still unclear ...
Xiaohan Yang, Ping Lin, Yunchen Luo, Huiru Bai, Xiaoqin Liao, Xin Li, Yuchen Tian, Beibei Jiang, Yuanzhi Pan, Fan Zhang, Lei Zhang, Yin Jia, Yan Li, Qinglin Liu   +13 more
doaj   +1 more source

Red blood cell glutathione peroxidase activity in female nulligravid and pregnant rats

Reproductive Biology and Endocrinology, 2009
Background The alterations of the glutathione peroxidase enzyme complex system occur in physiological conditions such as aging and oxidative stress consequent to strenuous exercise.
Martino Guglielmo, Gallo Giuseppe
doaj   +1 more source

Protective Effect of Wild Ginseng Extract against y-BHP-induced Oxidative Damage in HepG2 Cells Using DNA Chip

Journal of Pharmacopuncture, 2007
Objectives : This study was carried out to examine protective effect of wild ginseng extract on HepG2 human hepatoma cell line against tert-Butyl hydroperoxide (t-BHP)-induced oxidative damage.
Hyung-Seok Kim, Hee-Soo Park, Ki-Rok Kwon   +2 more
doaj   +1 more source

Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential

EMBO Molecular Medicine, 2021
Reactive oxygen species (ROS) regulates the replication of human immunodeficiency virus (HIV‐1) during infection. However, the application of this knowledge to develop therapeutic strategies remained unsuccessful due to the harmful consequences of ...
Shalini Singh, Sourav Ghosh, Virender Kumar Pal, MohamedHusen Munshi, Pooja Shekar, Diwakar Tumkur Narasimha Murthy, Govindasamy Mugesh, Amit Singh   +7 more
doaj   +1 more source

The Impact of Passive Smoking on Salivary Glutathione Peroxidase and Selenium in Relation to Dental Caries Severity among Five Years Old Children

Indian Journal of Dental Research, 2023
Background: It had been found that passive smoking may have the same harmful effect as tobacco cigarettes smoking. Aims: This study was conducted to determine the effect of passive smoking on salivary glutathione peroxidase and selenium in relation to ...
Shahba’a Munther, Baydaa Hussain Awn, Hiba N. Yassin   +2 more
doaj   +1 more source

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4.

Journal of Medicinal Chemistry, 2019
Glutathione peroxidase 4 (GPX4) is essential for cell membrane repair, inflammation suppression, and ferroptosis inhibition. GPX4 upregulation provides unique drug discovery opportunities for inflammation and ferroptosis-related diseases.
Cong Li, Xiaobing Deng, Weilin Zhang, Xiaowen Xie, M. Conrad, Y. Liu, J. Angeli, L. Lai   +7 more
semanticscholar   +1 more source