Results 51 to 60 of about 275,416 (288)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Glutathione cycle in diquat neurotoxicity: Assessed by intrastriatal pre-treatment with glutathione reductase [PDF]

Acta Veterinaria, 2013
Diquat (DQ) neurotoxicity mechanisms are unknown, although, it's systemic toxicity is mediated by free radical reactions. The role of glutathione cycle was assessed by glutathione reductase (GR) applied in the pre-treatment of DQ poisoning.
Đurđević Dragan, Đukić Mirjana, Ninković Milica, Stevanović Ivana, Jovanović Marina, Vasić Una   +5 more
doaj   +1 more source

Influence of salicylic acid on phytochelatin synthesis in Zea mays during Cd stress [PDF]

, 2013
: Presoaking maize (Zea mays) seeds in salicylic acid (SA) reduces damage caused by cadmium. In the present work the possible role of phytochelatins (PCs) in SA-mediated protection against Cd toxicity was investigated. Seeds were presoaked in 0.5 mM SA,
Janda, Tibor, Krantev, A., Popova, L. P., Szalai, Gabriella, Yordanova, R.   +4 more
core   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Effects of Various Drugs on Alcohol-induced Oxidative Stress in the Liver

Molecules, 2008
The major aim of this work was to investigate how alcohol-induced oxidative stress in combined chemotherapy changes the metabolic function of the liver in experimental animals.
Svetlana Trivic, Julijana Rasic, Biljana Kaurinovic, Snezana Janicijevic-Hudomal, Mira Popovic   +4 more
doaj   +1 more source

Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]

, 2011
The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
core  

Differential redox state contributes to sex disparities in the response to influenza virus infection in male and female mice [PDF]

, 2018
Influenza virus replicates intracellularly exploiting several pathways involved in the regulation of host responses. The outcome and the severity of the infection are thus strongly conditioned by multiple host factors, including age, sex, metabolic ...
Ann Maria Clemente, Anna Rita Vestri, Anna Teresa Palamara, Anna Teresa Palamara, Caterina Loredana Mammola, Danilo Alunni Fegatelli, Donatella Amatore, Enrico Garaci, Ignacio Celestino, Lucia Nencioni, Maria Gabriella Torcia, Marta De Angelis, Paola Checconi, Paola Matarrese, Paolo Coluccio, Romina Mancinelli, Rosanna Dattilo, Walter Malorni   +17 more
core   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function : Interaction with selenium and fatty acids [PDF]

, 2013
© 2013 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH Verlag GmbH & Co.
Akbaraly, Bellinger, Bermano, Bermano, Björnstedt, Brigelius-Flohé, Brigelius-Flohé, Drummen, Gautrey, Gong, Gu, Hayden, Hesketh, Kretz-Remy, Libby, Lubos, Mata, Mayer, Miller, Mozaffarian, Méplan, Phillips, Polonikov, Rayman, Sneddon, Sneddon, Sneddon, Sutherland, Thies, To, Udler, Villette   +31 more
core   +2 more sources

Antioxidant status in women with uterine leiomyoma: relation with sex hormones

Anais da Academia Brasileira de Ciências, 2015
Uterine leiomyomas are benign soft-tissues tumors that arise from uterine smooth muscle tissue. Etiopathogenesis of leiomyomas is not well understood. We aimed to examine whether antioxidant enzyme activities and lipid hydroperoxides level in patients ...
SNEŽANA PEJIĆ, ANA TODOROVIĆ, VESNA STOJILJKOVIĆ, LJUBICA GAVRILOVIĆ, NATAŠA POPOVIĆ, SNEŽANA B. PAJOVIĆ   +5 more
doaj   +1 more source