Plasmodium spp. membrane glutathione S-transferases: detoxification units and drug targets
Microbial Cell, 2014 Membrane glutathione S-transferases from the class of membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) form a superfamily of detoxification enzymes that catalyze the conjugation of reduced glutathione (GSH) to a broad ...
Andreas Martin Lisewski
doaj +2 more sources
Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients [PDF]
Genetics Research, 2023 Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials
Yan Zhang +4 more
doaj +2 more sources
Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility? [PDF]
Redox Biology, 2021 Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung allergens and irritants. Exposure to these substances can lead to inflammatory responses and may induce endogenous oxidant production, which can cause ...
Cheryl van de Wetering +9 more
doaj +2 more sources
Biological significance of glutathione S-transferases in human sperm cells [PDF]
Journal of Human Reproductive Sciences, 2019 Background: Oxidative stress is considered as one of the causes of male subfertility or infertility. Among antioxidant enzymes, the crucial role belongs to glutathione S-transferases (GSTs).
Roman V Fafula +6 more
doaj +2 more sources
Toxicity induced by Solanapyrone A in Chickpea shoots and its metabolism through Glutathione/Glutathione-S-Transferase system [PDF]
, 2013 Solanapyrone A and C were isolated from a Pakistani isolate of Ascochyta rabiei, Pk-1. Two experiments were conducted to investigate the phytotoxic effects of the most potent toxin, solanapyrone A on chickpea cultivars and its subsequent detoxification ...
Riaz, A. +5 more
core +7 more sources
Investigating the Potential Involvement of Glutathione S-Transferases in Defence Against Powdery Scab in Potato. [PDF]
J Fungi (Basel)Glutathione S-transferases (GSTs) are key enzymes in plant defences involved in detoxification, redox regulation, and the modulation of secondary metabolism, playing essential roles in the response to pathogen infections.
Balotf S, Wilson R, Wilson C.
europepmc +2 more sources
Glutathione S-Transferases in Marine Copepods
Journal of Marine Science and Engineering, 2021 The glutathione S-transferase (GST) is a complex family of phase II detoxification enzymes, known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds
Chiara Lauritano +2 more
doaj +1 more source
Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation. [PDF]
Biomolecules, 2022 Glutathione-S-transferases (GSTs) are highly promiscuous in terms of their interactions with multiple proteins, leading to various functions. In addition to their classical detoxification roles with multi-drug resistance-related protein-1 (MRP1), more ...
Russell TM, Richardson DR.
europepmc +2 more sources
The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes
Antioxidants, 2023 From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L-glutamyl-L-cysteinyl-glycine nucleophile tri-peptide, is the central player of
Corinne Cassier-Chauvat +4 more
doaj +1 more source
The Isolation and Identification of Anthocyanin-Related GSTs in Chrysanthemum
Horticulturae, 2021 Anthocyanin is the crucial pigment for the coloration of red chrysanthemum flowers, which synthesizes in the cytosol and is transported to the vacuole for stable storage.
Yajing Li +4 more
doaj +1 more source