Results 101 to 110 of about 223,107 (283)

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

The Role of Peroxiredoxin 6 in Cell Signaling

Antioxidants, 2018
Peroxiredoxin 6 (Prdx6, 1-cys peroxiredoxin) is a unique member of the peroxiredoxin family that, in contrast to other mammalian peroxiredoxins, lacks a resolving cysteine and uses glutathione and π glutathione S-transferase to complete its ...
José A. Arevalo, José Pablo Vázquez-Medina   +1 more
doaj   +1 more source

Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian [PDF]

, 2009
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung cancer in Mongolia of China.
Fuhou Chang, Guang Wang, Jia Ma, Jun QI, Min-jie Wang, Qin Yin, Zhi-Xie Zhang   +6 more
core   +1 more source

Defect‐Rich 2D Layered Double Hydroxides Enhance Sonodynamic Antibacterial Therapy

Advanced Science, EarlyView.
This study develops defect‐rich ultrathin ZnCuW‐LDH nanosheets (DR‐ZnCuW‐LDH) via acid etching. DR‐ZnCuW‐LDH exhibits fourfold enhanced US‐triggered ROS production due to oxygen defects and electronic modulation, demonstrating potent antibacterial efficacy in vitro/vivo.
Qian Liu, Yu Yang, Rui Zhao, Linwei Huang, Xingyu Qi, Min Wu, Jianliang Shen   +6 more
wiley   +1 more source

A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita [PDF]

, 2018
© The Author(s). 2018Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops.
A Clark, AF Bird, AG Whitehead, AJ van Rossum, AN Nathoo, AR Hipkiss, AR Quinlan, B Boettner, B Ketterer, B Li, B Mannervik, B Raymond, C The, CA Perrett, CA Reinitz, CD Sifri, D Wong, DL McEwan, E Moreno-Arriola, E Peter, EE Penhoet, EL Pavlova, ES Kim, FA Partridge, FX Yu, G Simons, H Li, HR Nicholas, I Mohr, IK Vagelas, IR Cohen, Irene Bricchi, J Heino, J Papadopoulou, J Tang, J. P. Yan, JA Melo, JF Preston, K Hesp, K Kim, K. G. DAVIES, Keith G. Davies, KG Bankar, KG Davies, KG Davies, KG Davies, KG Davies, KH Nomura, KJ Livak, L Charles, L Lambrechts, L Lambrechts, LB Cohen, LE Waggoner, M Cohen, M Klass, MA Bakowski, MA Miller, ME Feder, MG Grabherr, MJ Gravato-Nobre, MR Calgaro, MS Gami, MS Kwa, N Borghi, N Kogata, N Lane, N Schormann, N Tavernarakis, N Tavernarakis, N Vibanco-P’erez, O Silva-García, P Abad, P. B. Szecsi, PE Kuwabara, PE Urwin, PK Papolu, PM Brophy, PM Brophy, PM Guimaraes, R Erion, R Roberts, RK Patel, RM Sayre, Rohit N. Shukla, S Anders, S Choi, S Das, S Echevarria-Zomeno, S Mahajan-Miklos, SC Johnson, SC Zevian, SE Chang, SF Altschul, SHE Kaufmann, SJ McTaggart, SM Barribeau, TE Hewlett, TJ Krieger, TL Dunbar, TM Kubiak, TM Roberts, TM Shinnick, U Rao, Uma Rao, V Giguere, V Phani, V Phani, V Phani, Victor Phani, Victor Phani, Vishal S. Somvanshi, X Chen, X Zou, Y Gonskikh, Y Moriya, Y Spiegel, Y Yarden, Y Zhang   +118 more
core   +2 more sources

Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

Advanced Science, EarlyView.
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang, Yajian Li, Xiaoyin Lv, Jianmei Guo, Yijia Zhang, Yuqi Lin, Kaili Nie, Jian Zeng, Ming Zhang, Qiong Dai   +9 more
wiley   +1 more source

Grape Seed Polyphenols Enhance Antioxidant Activity and Prolong the Lifespan of Caenorhabditis elegans Through SKN‐1/Nrf2 Pathway

AgriFood: Journal of Agricultural Products for Food, EarlyView.
GSP extends C. elegans lifespan, enhances stress resistance and reproduction, boosts antioxidant defenses (↑SOD/CAT/GSH‐Px, ↓ROS), remodels glycolysis/TCA/one‐carbon metabolism dose‐dependently, and activates SKN‐1/Nrf2 and H3K4 methylation—linking redox control to epigenetic modulation.
Boya Ouyang, Quanyong Wu, Fei Liu, Jingyimei Liang, Wanning Ma, Yuxuan Zhao, Hui Cao, Jianbo Xiao   +7 more
wiley   +1 more source

Enzymes Involved in Antioxidant and Detoxification Processes Present Changes in the Expression Levels of Their Coding Genes under the Stress Caused by the Presence of Antimony in Tomato

Plants
Currently, there is an increasing presence of heavy metals and metalloids in soils and water due to anthropogenic activities. However, the biggest problem caused by this increase is the difficulty in recycling these elements and their high permanence in ...
Francisco Luis Espinosa-Vellarino, Inmaculada Garrido, Ilda Casimiro, Ana Cláudia Silva, Francisco Espinosa, Alfonso Ortega   +5 more
doaj   +1 more source

Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility

Acta Biomedica Scientifica, 2018
Background. Genetic factors cause 30-50 % of cases of male infertility different forms. We have conducted the investigation of the lipid peroxidation and antioxidant protection system components, associated with the biotransformation genes polymorphisms,
N. A. Kurashova, T. A. Bairova, M. I. Dolgikh, E. V. Osipova, B. G. Dashiev, A. V. Labygina, I. N. Gutnik, I. M. Mikhalevich, L. I. Kolesnikova   +8 more
doaj   +1 more source