Results 111 to 120 of about 223,107 (283)

A Comparative Study Between Alcoholics of Koraga Community, Alcoholics of General Population and Healthy Controls for Antioxidant Markers and Liver Function Parameters [PDF]

, 2010
Objectives: It is well established that long-term alcohol consumption leads to liver cirrhosis and other related disorders. Sufficient work has been done on biochemical markers of liver damage and antioxidant status of chronic alcoholics in general ...
Anwar, N, Bhandary, PV, Devaramane, V, Kedage, V, Muttigi, MS, Prabhu, LS, Prakash, M, Shetty, MS, Tilak, P   +8 more
core  

Protein Expression, Characterization and Activity Comparisons of Wild Type and Mutant DUSP5 Proteins [PDF]

, 2014
Background The mitogen-activated protein kinases (MAPKs) pathway is critical for cellular signaling, and proteins such as phosphatases that regulate this pathway are important for normal tissue development.
Gastonguay, Adam J., Jensen, David R., Kalous, Kelsey S, Kutty, Raman G., Nayak, Jaladhi, Pokkuluri, Phani Raj, Ramchandran, Ramani, Rathore, Rajendra, Sem, Daniel S., Span, Elise A., Talipov, Marat R., Vakeel, Padmanabhan   +11 more
core   +2 more sources

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

A relação do uso crônico de fenobarbital com áreas potencialmente pré-neoplásicas em fígado de ratos Potentially pre-neoplasics areas in rat's liver associated to chronic use of phenobarbital

Arquivos de Gastroenterologia, 2006
RACIONAL: O fenobarbital é utilizado em modelos experimentais não só por ser um importante agente promotor da carcinogênese em fígado de ratos, como também por ser não-genotóxico, órgão-específico e dose-dependente.
Helena Terezinha Hubert Silva, Antonio Atalíbio Hartmann   +1 more
doaj   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Glutathione transferases: new functions

Current Opinion in Structural Biology, 2005
Well known as detoxification enzymes, the glutathione transferases also function in prostaglandin and steroid hormone synthesis. New uses for the canonical glutathione transferase fold are becoming apparent; the bacterial stringent starvation protein SspA and the yeast prion protein Ure2p (both transcription factors) were found to adopt this fold, but ...
openaire   +3 more sources

The Role of Arginase and some Parameters in Diabetic Type 2 Patients with and without Retinopathy

مجلة كلية الطب
Background: Oxidative stress plays a major role in the pathogenesis of diabetes mellitus by damaging cellular organelles and enzymes in blood such as arginase1, insulin and glutathione s-transferase; increasing lipid peroxidation such as malondialdehyde
Maha F. Yassen, Fayhaa. M. Khaleel
doaj   +1 more source

Two pear glutathione S-transferases genes are regulated during fruit development and involved in response to salicylic acid, auxin, and glucose signaling.

PLoS ONE, 2014
Two genes encoding putative glutathione S-transferase proteins were isolated from pear (Pyrus pyrifolia) and designated PpGST1 and PpGST2. The deduced PpGST1 and PpGST2 proteins contain conserved Glutathione S-transferase N-terminal domain (GST_N) and ...
Hai-Yan Shi, Zheng-Hong Li, Yu-Xing Zhang, Liang Chen, Di-Ying Xiang, Yu-Feng Zhang   +5 more
doaj   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Human Glutathione Transferase Zeta

, 2005
Zeta-class glutathione transferases (GSTZs) were recently discovered by a bioinformatics approach and the availability of human expressed sequence tag databases. Although GSTZ showed little activity with conventional GST substrates (1-chloro-2,4-dinitrobenzene; organic hydroperoxides), GSTZ was found to catalyze the oxygenation of dichloroacetic acid ...
Board, Philip, Anders, Michael
openaire   +3 more sources