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The glutathione peroxidase activity of glutathione S-transferases
Biochimica et Biophysica Acta (BBA) - Enzymology, 1980Glutatione transferases (RX:glutathione R-transferases, EC 2.5.1.18) B and AA were purified from rat liver to investigate the mechanism for their apparent GSH peroxidase activity (GSSG formation). Both transferases catalyze an overall reaction in which loss of cumene hydroperoxide is accompanied by a stoichiometric increase in GSSG.
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Human Glutathione S-Transferases
Seminars in Liver Disease, 1998Human glutathione S-transferases (GSTs) are a functionally diverse family of soluble enzymes of detoxification that use reduced glutathione (GSH) in conjugation and reduction reactions. Toxic electrophiles, including a variety of carcinogens, are substrates for the GSTs and after conjugation or reduction they are more easily excreted into bile or urine.
R, Whalen, T D, Boyer
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Glutathione Transferases in the Bioactivation of Azathioprine
2014The prodrug azathioprine is primarily used for maintaining remission in inflammatory bowel disease, but approximately 30% of the patients suffer adverse side effects. The prodrug is activated by glutathione conjugation and release of 6-mercaptopurine, a reaction most efficiently catalyzed by glutathione transferase (GST) A2-2.
Olof, Modén, Bengt, Mannervik
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Glutathione transferases: Nomenclature
Biochemical Pharmacology, 1984W B, Jakoby, B, Ketterer, B, Mannervik
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Phylogenies of Glutathione Transferase Families
2005The best known glutathione transferase family, with its class-alpha, -mu, -pi, -omega, -sigma, -theta, and -zeta subdivisions, is only one of four, or perhaps five, ancient protein families that conjugate glutathione or use a glutathione intermediate: (1) the cytoplasmic family, (2) the mitochondrial (kappa) family, (3) the microsomal (MAPEG) family ...
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Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1
Antioxidants, 2023Marina Sagnou +2 more
exaly
Interaction of haloacetonitriles with glutathione and glutathione-S-transferase
Biochemical Pharmacology, 1989E L, Lin, C W, Guion
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