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Integrative Zoology, EarlyView.This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu +5 more
wiley +1 more source
Integrative Zoology, EarlyView.High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang +6 more
wiley +1 more source
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Potentiometric Determination of Glutathione and Glutathione Transferase Activity
Analytical Letters, 1991Abstract A new method of determination of Glutathione Transferase activity (GST) and Glutathione (GSH) in solution has been developed. The determination was performed by detection of ions (H+, Cl−, F−) produced during the GST catalyzed reaction using ion-selective electrodes.
Dario Compagnone +2 more
exaly +3 more sources
Annual Review of Pharmacology and Toxicology, 2005
▪ Abstract This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated MAPEG. Besides detoxifying electrophilic xenobiotics, such as chemical carcinogens, environmental pollutants, and antitumor agents, these transferases inactivate endogenous α,β ...
Hayes, John D. +2 more
openaire +4 more sources
▪ Abstract This review describes the three mammalian glutathione transferase (GST) families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated MAPEG. Besides detoxifying electrophilic xenobiotics, such as chemical carcinogens, environmental pollutants, and antitumor agents, these transferases inactivate endogenous α,β ...
Hayes, John D. +2 more
openaire +4 more sources
Measurement of Glutathione Transferases
Current Protocols in Toxicology, 2002AbstractThere are multiple glutathione transferase genes, the proteins for which have different substrate specificities. The various genes are differentially expressed such that species and organs and tissues differ qualitatively and quantitatively for cytosolic and membrane‐bound forms. This unit provides protocols for analysis of transferase activity
B, Mannervik, P, Jemth
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Insect glutathione transferases
Drug Metabolism Reviews, 2011This article is an overview of the current knowledge of insect glutathione transferases. Three major topics are discussed: the glutathione transferase contributions to insecticide resistance, the polymorphic nature of the insect glutathione transferase superfamily, and a summary of the current structure-function studies on insect glutathione ...
Albert J, Ketterman +2 more
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Glutathione Transferases and Cancer
Critical Reviews in Biochemistry and Molecular Biology, 1992The glutathione transferases, a family of multifunctional proteins, catalyze the glutathione conjugation reaction with electrophilic compounds biotransformed from xenobiotics, including carcinogens. In preneoplastic cells as well as neoplastic cells, specific molecular forms of glutathione transferase are known to be expressed and have been known to ...
S, Tsuchida, K, Sato
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1996
Glutathione (GSH), the most ubiquitous and abundant nonprotein thiol, is essential in numerous detoxification reactions and is therefore considered a chemoprotectant. In the human, levels of GSH range from 30μM in plasma to 3mM in kidney proximal tubules; tumors of various organs can contain up to 10mM GSH [1].
A, Raha, K D, Tew
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Glutathione (GSH), the most ubiquitous and abundant nonprotein thiol, is essential in numerous detoxification reactions and is therefore considered a chemoprotectant. In the human, levels of GSH range from 30μM in plasma to 3mM in kidney proximal tubules; tumors of various organs can contain up to 10mM GSH [1].
A, Raha, K D, Tew
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Glutathione Transferases and Carcinogenesis
1986Carcinogenesis has been regarded as being divisible into at least 3 major phases: (a) initiation, a largely irreversible process which has been compared to mutation; (b) promotion, a process during which cells undergo phenotypic changes, some of which are referred to as preneoplastic, and a proportion of which attain autonomy when they can be regarded ...
B, Ketterer +4 more
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Mosquito Glutathione Transferases
2005The glutathione transferases (glutathione S-transferases, GSTs) are a diverse family of enzymes involved in a wide range of biological processes, many of which involve the conjugation of the tripeptide glutathione to an electrophilic substrate. Relatively little is known about the endogenous substrates of mosquito GSTs, and most studies have focused on
Hilary, Ranson, Janet, Hemingway
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