Results 51 to 60 of about 224,471 (305)

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Antioxidants selenomethionine and D-pantethine differentially affect doxorubicin’s action on glutathione system in human leukemia cells varying in their resistance to chemotherapy in vitro

Біологічні студії, 2018
Rapid development of multiple drug resistance and occurrence of negative side effects in cancer patients arising at the treatment belong to the main problems in cancer chemotherapy.
Yu. S. Kozak, R. R. Panchuk, N. R. Skorokhyd, D. S. Semenovich, A. G. Moiseenok, R. S. Stoika   +5 more
doaj   +1 more source

Toxicity induced by Solanapyrone A in Chickpea shoots and its metabolism through Glutathione/Glutathione-S-Transferase system [PDF]

, 2013
Solanapyrone A and C were isolated from a Pakistani isolate of Ascochyta rabiei, Pk-1. Two experiments were conducted to investigate the phytotoxic effects of the most potent toxin, solanapyrone A on chickpea cultivars and its subsequent detoxification ...
Abdur Rauf, C., Haque, I., Naz, F., Nicklin, Jane, Qadir, G., Riaz, A.   +5 more
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism

Журнал инфектологии, 2017
In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1).
N. A. Stepanova, Kh. M. Galimzyanov, B. I. Kantemirova   +2 more
doaj   +1 more source

Stage-specific proteomes from onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle [PDF]

, 2016
Despite 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected.
Adam, Altschul, Altschul, Anon, Argueta, Armstrong, Armstrong, Arumugam, Babayan, Bazzocchi, Bendtsen, Benjamini, Bennuru, Bennuru, Berry, Berry, Board, Boatin, Brattig, Brattig, Brophy, Bulman, Burbelo, Burchard, Burket, Butler, Chandrashekar, Chawade, Chhabra, Choi, Claros, Constam, Cooray, Crump, Darby, Darby, Desjardins, Duckert, Edgar, Edwards, Erttmann, Finn, Franceschini, Frank, Gallin, Gardon, GBD 2013 Mortality and Causes of Death Collaborators, Geary, Ghali, Ghedin, Ghosh, Gilbert, Globisch, Godel, Gomez-Escobar, Gopal, Gotenstein, Gottsch, Grainger, Gretes, Guan, Guiliano, Hansen, Henrichfreise, Hewitson, Hewitson, Hewitson, Hotez, Hunter, Ichishita, Joseph, Joza, Kanazawa, Klion, Ko, Koonin, Korten, Krogh, Larkin, Li, Li, Liebau, Liebau, Liebau, Liebau, Littler, Liu, Longo, Lu, Lundquist, Lustigman, Lustigman, Mackenzie, Makepeace, Marti, McGarry, McSorley, Melnikow, Meyer, Michalski, Morales-Hojas, Moreno, Moreno, Morris, Mossmann, Nana-Djeunga, Nfon, Nicholson, Nomura, Ohtsuki, Ohtsuki, Osei-Atweneboana, Page, Pant, Parra, Petersen, Plaisier, Quintana, Ranjan, Rew, Rogalski, Roth, Saitou, Schulz-Key, Schulz-Key, Scocchi, Sheehan, Silva, Sommer, Srivastava, Tamarozzi, Tanikawa, Taylor, Tchakouté, Ternent, Tew, Thompson, Tiwari, Trees, Vogel, Wahl, Waterhouse, Westermann, Wildenburg, Willenbucher, Wilson, Wisniewski, Wu, Wu, Xie, Xie, Yamaguchi, Yang, Yasuda, Zanetti, Zipfel   +155 more
core   +6 more sources

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Influence of Two Depuration Periods on the Activity and Transcription of Antioxidant Enzymes in Tilapia Exposed to Repeated Doses of Cylindrospermopsin under Laboratory Conditions

Toxins, 2014
The cyanobacterial toxin Cylindrospermopsin (CYN), a potent protein synthesis inhibitor, is increasingly being found in freshwater bodies infested by cyanobacterial blooms worldwide.
Victoria Ríos, Remedios Guzmán-Guillén, Isabel M. Moreno, Ana I. Prieto, María Puerto, Angeles Jos, Ana M. Cameán   +6 more
doaj   +1 more source

Method of identifying inhibitors of glutathione S-transferase (GST) gene expression [PDF]

, 1999
Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer.
Akande, Olanike, Ali-Osman, Francis, Antoun, Gamil, Buolamwini, John K., Keller, Charles W., Lo, Hui-Wen, Lopez-Berestein, Gabriel   +6 more
core   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source