Results 91 to 100 of about 144,829 (355)
Advanced Science, EarlyView.Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce +8 more
wiley +1 more source
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Advanced Science, EarlyView.Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter +4 more
wiley +1 more source
, 2014 Citation: 'glycans' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.G02645 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial usage
openaire +1 more source
Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source
Advanced Plant-Based Glycan Engineering
Frontiers in Bioengineering and Biotechnology, 2018 With respect to biomanufacturing, glycosylation is one of the most addressed post-translational modifications, since it is well-known that the attachment of sugar residues efficiently affects protein homogeneity and functionality.
Laura Montero-Morales, H. Steinkellner
semanticscholar +1 more source
Advanced Science, EarlyView.Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon +8 more
wiley +1 more source
mBio, 2020 NTHi is a human-adapted pathogen that colonizes the human respiratory tract. Strains of NTHi express multiple adhesins; however, there is a unique, mutually exclusive relationship between the major adhesins Hia and HMW1 and HMW2 (HMW1/2).
John M. Atack +9 more
doaj +1 more source
Analysis and validation of overall N-glycan conformation in Privateer [PDF]
, 2023 Jordan S. Dialpuri +6 more
openalex +1 more source
Advanced Science, EarlyView.This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue +13 more
wiley +1 more source
Microbe-focused glycan array screening platform
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The interplay between glycan binding proteins and their carbohydrate ligands is fundamental to all aspects of life. Printed glycan arrays have helped to elucidate the role of glycans in many biological processes with monosaccharide ...
Andreas Geissner +26 more
semanticscholar +1 more source