Results 111 to 120 of about 144,829 (355)
Advanced Science, EarlyView.Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Zhishan Xu +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.7‐O‐, 9‐O‐, and 7,9‐di‐O‐acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α‐glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by O‐acetyl editing by coronaviral hemagglutinin‐esterases (HEs).
Zhiyong Zhang +5 more
wiley +2 more sources
Evaluation of Preferential Cytokine Adsorption onto Biosensing Surface Modified with Glycopolymer
BiosensorsFor the improvement of biosensor performance, the development of a molecular recognition material as well as a sensor platform is necessary. A glycopolymer is a molecular recognition material capable of recognizing specific proteins as natural glycans ...
Yuhei Terada +3 more
doaj +1 more source
The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human
Microorganisms, 2018 Glycoproteins are major players in the mucus protective barrier in the gastrointestinal and other mucosal surfaces. In particular the mucus glycoproteins, or mucins, are responsible for the protective gel barrier.
Anthony P. Corfield
doaj +1 more source
Advanced Science, EarlyView.A novel ellipsometry platform functionalized with truncated PD‐L1 aptamers are developed to enable ultrasensitive detection of BALF‐derived exosomes. Through chemical ligand tailoring, mechanical sensing optimization, and tumor‐proximal fluid sampling, the system precisely stratifies ICI responders and non‐responders, offering superior sensitivity and ...
Euna Jeong +15 more
wiley +1 more source
Water Networks as Hydrophobic Recognition Motifs in Proteins
Angewandte Chemie, EarlyView.Hydrophobic groups can strengthen confined water networks, promoting order that propagates through the protein structure and drives recognition, creating a paradoxical hydrophobic binding hot spot. Polar groups are rejected because they disrupt the network, destabilizing the protein structure.
Serena G. Piticchio +12 more
wiley +2 more sources
N-glycan microheterogeneity regulates interactions of plasma proteins
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Glycosylation is one of the most common and complex posttranslation modifications that significantly influences protein structure and function.
Di Wu +4 more
semanticscholar +1 more source
MedChemComm, 2019 Exploiting glycan recognition in drug discovery.
Pablo Valverde +4 more
openaire +4 more sources
Advanced Science, EarlyView.DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.A total of 16 chemically synthesized capsular polysaccharide (CPS) fragments related to Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii were analyzed by glycan microarray. Comparative screening revealed three conserved epitopes that act as cross‐protective vaccine lead candidates against multidrug‐resistant (MDR) bacterial ...
Amar Kumar Mishra +9 more
wiley +2 more sources