Results 111 to 120 of about 181,761 (403)

Biofilm Control by Active Topography with Mucin Coating

Advanced Functional Materials, EarlyView.
This study reports a new antifouling strategy based on a bioinspired design. Mucin coating enhances biofilm control by active topography with beating micron‐sized pillars. Besides the mechanical force of beating pillars, the antibiofilm activities also involve biological factors since mucin coating inhibits swarming motility and c‐di‐GMP synthesis in ...
Zehui Han, Yikang Xu, Huan Gu, Teng Zhang, Dacheng Ren   +4 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

Advanced Materials, EarlyView.
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew, Erlantz Lizundia, Mark J. MacLachlan   +2 more
wiley   +1 more source

A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2 [PDF]

, 2015
Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the ...
Drickamer, K, Dungarwalla, T, Feinberg, H, Jégouzo, SAF, Taylor, ME, Weis, WI   +5 more
core   +1 more source

Structure and Immune Recognition of the HIV Glycan Shield.

Annual Review of Biophysics, 2018
Vaccine design efforts against the human immunodeficiency virus (HIV) have been greatly stimulated by the observation that many infected patients eventually develop highly potent broadly neutralizing antibodies (bnAbs).
M. Crispin, A. Ward, I. Wilson
semanticscholar   +1 more source

Interfacial Yield Stress Response in Synthetic Mucin Solutions

Advanced Materials Interfaces, EarlyView.
The solution rheology of novel synthetic mucins mimicking natural mucin domains is studied. Like many natural mucin solutions, apparent solid‐like rheology is seen. However, no bulk structural features are found to explain it. Interfacial rheology and robust modelling reveal that this arises from molecular associations at the air–water interface ...
Sumit Sunil Kumar, Travis Leadbetter, J. Brandon McClimon, Manuel A. Lema, Farhana M. Khan, Prashant K. Purohit, Adam B. Braunschweig, Robert W. Carpick   +7 more
wiley   +1 more source

Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins [PDF]

, 2019
Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the
Adamczyk, Barbara, Chahal, Gurdeep, Ducatelle, Richard, Erhardsson, Mattias, Flahou, Bram, Haesebrouck, Freddy, Jin, Chunsheng, Karlsson, Niclas G, Linden, Sara K, Padra, Medea, Smet, Annemieke, Thorell, Anders   +11 more
core   +1 more source

Advanced Plant-Based Glycan Engineering

Frontiers in Bioengineering and Biotechnology, 2018
With respect to biomanufacturing, glycosylation is one of the most addressed post-translational modifications, since it is well-known that the attachment of sugar residues efficiently affects protein homogeneity and functionality.
Laura Montero-Morales, H. Steinkellner
semanticscholar   +1 more source

Biological roles of glycans [PDF]

Glycobiology, 2016
Simple and complex carbohydrates (glycans) have long been known to play major metabolic, structural and physical roles in biological systems. Targeted microbial binding to host glycans has also been studied for decades. But such biological roles can only explain some of the remarkable complexity and organismal diversity of glycans in nature.
openaire   +3 more sources