Results 131 to 140 of about 181,761 (403)

Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens [PDF]

, 2010
Presently some three hundred post-translational modifications are known to occur in bacteria in vivo. Many of these modifications play critical roles in the regulation of proteins and control key biological processes.
Graham, Robert L. J., Hess, Sonja
core   +1 more source

Microbe-focused glycan array screening platform

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The interplay between glycan binding proteins and their carbohydrate ligands is fundamental to all aspects of life. Printed glycan arrays have helped to elucidate the role of glycans in many biological processes with monosaccharide ...
Andreas Geissner, A. Reinhardt, C. Rademacher, T. Johannssen, J. T. Monteiro, B. Lepenies, M. Thépaut, F. Fieschi, J. Mrázková, M. Wimmerová, Frank Schuhmacher, S. Götze, Dan Grünstein, Xiaoqiang Guo, H. S. Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher Martin, S. Parameswarappa, Sandip Pasari, M. Schlegel, Hide-Nori Tanaka, Guozhi Xiao, You Yang, C. Pereira, C. Anish, P. Seeberger   +26 more
semanticscholar   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

The glycans of stem cells [PDF]

Current Opinion in Chemical Biology, 2007
Glycans cover all cellular surfaces and, not surprisingly, are involved in many facets of stem cell biology and technology. For instance, coaxing stem cells to either proliferate or differentiate into the specific cell types needed for transplantation requires intricate glycan-dependent modulation of signalling molecules such as FGF-2, Wnt, and Notch ...
Pascal M Lanctot, Ajit Varki, Fred H. Gage   +2 more
openaire   +3 more sources

Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling

Advanced Science, EarlyView.
The comprehensive proteomic and N‐glycoproteomic analyses of 45 colorectal cancer tissues with matched normal adjacent tissues identified 7125 intact N‐glycopeptides from 704 glycoproteins. A glycosylation site‐protein function network revealing metabolic dysregulation is constructed and a model differentiating tumors from normal tissues is developed ...
Guobin Liu, Lu Chen, Jingxiang Zhao, Yue Jiang, Yarong Guo, Xiang Mao, Xuelian Ren, Kun Liu, Qi Mei, Qunyi Li, He Huang   +10 more
wiley   +1 more source

Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan*

Molecular & Cellular Proteomics, 2019
Bisecting GlcNAc, a branching sugar in N-glycan highly expressed in brain, is involved in Alzheimer's disease, but its physiological function is largely unclear.
M. Nakano, S. Mishra, Y. Tokoro, Keiko Sato, K. Nakajima, Y. Yamaguchi, N. Taniguchi, Yasuhiko Kizuka   +7 more
semanticscholar   +1 more source

Insights into Siglec‐7 Binding to Gangliosides: NMR Protein Assignment and the Impact of Ligand Flexibility

Advanced Science, EarlyView.
The molecular recognition of the sugar moiety of GD3 and Gb3 (globotriaosylceramide) derivatives by Siglec‐7 has been thoroughly studied offering insights for cancer diagnostics and therapies. A combination of structural biology techniques, nuclear magnetic resonance (NMR) spectroscopy, physicochemical analysis, and in silico methods suggested that ...
Cristina Di Carluccio, Luis Padilla‐Cortés, Marta Tiemblo‐Martìn, Giulia Roxana Gheorghita, Rosario Oliva, Linda Cerofolini, Alessandro Antonio Masi, Celeste Abreu, Hsin‐Kai Tseng, Antonio Molinaro, Pompea Del Vecchio, Ondřej Vaněk, Chun‐Cheng Lin, Roberta Marchetti, Marco Fragai, Alba Silipo   +15 more
wiley   +1 more source

Reshaping and Enzymatic Activity may allow Viruses to move through the Mucus [PDF]

arXiv, 2023
Filamentous viruses like influenza and torovirus often display systematic bends and arcs of mysterious physical origin. We propose that such viruses undergo an instability from a cylindrically symmetric to a toroidally curved state. This ``toro-elastic'' state emerges via spontaneous symmetry breaking under prestress due to short range spike protein ...
arxiv  

Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]

, 2008
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core   +2 more sources

Visualization of the HIV-1 Env glycan shield across scales

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The HIV-1 Env “glycan shield” masks the surface of the protein from immune recognition, yet intrinsic heterogeneity defies a typical structure–function description.
Z. Berndsen, Srirupa Chakraborty, Xiaoning Wang, C. Cottrell, J. Torres, J. Diedrich, Cesar A. López, J. Yates, M. V. van Gils, J. Paulson, S. Gnanakaran, A. Ward   +11 more
semanticscholar   +1 more source