Results 141 to 150 of about 181,761 (403)
Advanced Science, EarlyView.In the tumor margin of hepatocellular carcinoma (HCC), activated hepatic stellate cells upregulate MTFR2, initiating inhibiting DRP1 degradation and mitochondrial fission. This enhances mitochondrial availability and facilitates FAs synthesis via ACC1. Additionally, fission promotes RAC1‐mediated cytoskeletal remodeling and Miro1‐mediated mitochondrial
La Zhang +9 more
wiley +1 more source
Comparative genomic analysis of the human gut microbiome reveals a broad distribution of metabolic pathways for the degradation of host-synthetized mucin glycans [PDF]
arXiv, 2017 The colonic mucus layer is a dynamic and complex structure formed by secreted and transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins. Colonic mucus consists of a loose outer layer and a dense epithelium-attached layer. The outer layer is inhabited by various representatives of the human gut microbiota (HGM). Glycans
arxiv
Object classification in analytical chemistry via data-driven discovery of partial differential equations [PDF]
arXiv, 2020 Glycans are one of the most widely investigated biomolecules, due to their roles in numerous vital biological processes. This involvement makes it critical to understand their structure-function relationships. Few system-independent, LC-MS/MS (Liquid chromatography tandem mass spectrometry) based studies have been developed with this particular goal ...
arxiv
Electronic Single Molecule Identification of Carbohydrate Isomers by Recognition Tunneling [PDF]
, 2016 Glycans play a central role as mediators in most biological processes, but their structures are complicated by isomerism. Epimers and anomers, regioisomers, and branched sequences contribute to a structural variability that dwarfs those of nucleic acids and proteins, challenging even the most sophisticated analytical tools, such as NMR and mass ...
arxiv +1 more source
Glycan Microarrays as Chemical Tools for Identifying Glycan Recognition by Immune Proteins
Frontiers in Chemistry, 2019 Glycans and glycan binding proteins (GBPs or lectins) are essential components in almost every aspect of immunology. Investigations of the interactions between glycans and GBPs have greatly advanced our understanding of the molecular basis of these ...
Chao Gao +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.A reversible wet chemical surface functionalization results in dynamic multivalent receptors showing ligand‐specific high affinity for lectins and bacteria. Abstract The paper reports the design of multivalent bacterial receptors based on reversible self‐assembled monolayers (rSAMs) on gold and glass substrates, mimicking the ligand display on host ...
Thomas Hix‐Janssens +12 more
wiley +1 more source
N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors
Frontiers in Molecular Neuroscience, 2018 N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of GluN1 ...
Kristyna Skrenkova +11 more
doaj +1 more source
Computationally Discovered Potentiating Role of Glycans on NMDA Receptors [PDF]
arXiv, 2016 N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate these effects.
arxiv
O -Acetylated sugars in the gas phase: stability, migration, positional isomers and conformation [PDF]
Physical Chemistry Chemical Physics, 2022, 24 (2), pp.1016-1022O-acetylations are functional modifications which can be found on different hydroxyl groups of glycans and which contribute to the fine tuning of their biological activity. Localizing the acetyl modifications is notoriously challenging in glycoanalysis, in particular because of their mobility: loss or migration of the acetyl group may occur through the
arxiv +1 more source
Mutational analysis of the carbohydrate binding activity of the tobacco lectin [PDF]
, 2010 At present the three-dimensional structure of the tobacco lectin, further referred to as Nictaba, and its carbohydrate-binding site are unresolved. In this paper, we propose a three-dimensional model for the Nictaba domain based on the homology between ...
Barre, Annick +6 more
core +2 more sources